Virtual Reality for Non-cardiac Chest Pain

This study is exploring whether virtual reality (VR) therapy can help improve symptoms for people experiencing non-cardiac chest pain (NCCP). NCCP is chest pain that isn't caused by heart problems. The study aims to see if VR is a practical and helpful treatment option. Researchers will look at how willing people are to join, how well they stick with the VR therapy, and if it helps with pain, anxiety, and quality of life. You may be able to join if you are 18 or older, have NCCP symptoms, and have had a heart evaluation that ruled out cardiac issues. The study is currently unclear on its recruitment status and plans to enroll 10 participants.

Study design
This is an interventional study with a planned enrollment of 10 participants. The phase of the study is not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, such as changes in GERD (Gastroesophageal Reflux Disease) symptoms and quality of life, are measured at Week 2.

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NCT06262126

Virtual Reality for Non-cardiac Chest Pain

Recruiting
NAAges 18+InterventionalSupportive care
Mayo Clinic
~10 participants
Updated 2026-02-12 on ClinicalTrials.gov
What's tested:Virtual Reality

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measure changes in GERD symptoms using the GERDQ questionnare
Measured over Week 2
+4 more outcomes measured
Gastrointestinal Diseases
Chest Pain
1 sites across 1 states
Florida1
  • Andree Koop, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

Symptoms of non-cardiac chest pain (recurrent anginal-like or atypical chest pain)
Negative prior cardiac evaluation (at a minimum, including electrocardiogram)
Prior esophagogastroduodenoscopy and/or barium esophagram to rule out severe esophagitis, stricture, or motility abnormality

Exclusion

Initiation of a proton pump inhibitor (PPI) within 8 weeks
Major concomitant illness
Current drug or alcohol use that that would interfere with adherence to study requirements
Symptoms of vertigo or dizziness that would limit tolerability of the VR headset
  • Measure changes in GERD symptoms using the GERDQ questionnareWeek 2

    Gastroesophageal reflux disease (GERD) questionnaire (GerdQ) is a 6-item questionnaire (scale from 0 to 18) that measures heartburn, regurgitation, abdominal pain, nausea, sleep disorders, and the over-the-counter (OTC) drugs use. The score predicts the likelihood of GERD, with a score between 11-18 suggesting 89% or greater likelihood.

  • Measure changes in GERD quality of life using the GERD-HRQL questionnaireWeek 2

    GERD-HRQL- Gastroesophageal reflux disease (GERD) - Health Related Quality of Life (HRQL) The scale has 15 items, which focus on heartburn symptoms, dysphagia, medication effects and health condition. Each item is scored from 0 to 5 (maximum score 75), with a higher score indicating a better QOL

  • Measure changes in esophageal symptom specific anxiety using the EHAS questionnaireWeek 2

    The esophageal hypervigilance and anxiety scale (EHAS) The EHAS is a 15-item measure with two factors evaluating esophageal hypervigilance and symptom specific anxiety scored on a 0-4 Likert scale. Items are summed to yield a total score ranging from 0 - 60 (Greater hypervigilance/anxiety).

  • Measure changes in GI symptom severity using the PAGI-SYM questionnaireWeek 2

    Patient Assessment of Gastrointestinal Disorders-Symptom Severity Index (PAGI-SYM) The PAGI-SYM includes 6 subscales ranging from 0 (none) to 5 (very severe): heartburn/regurgitation, fullness/early satiety, nausea/vomiting, bloating, upper abdominal pain, and lower abdominal pain.

  • Measure changes in GI related patient assessment of quality of life using PAGI-QOLWeek 2

    Patient Assessment of Gastrointestinal Disorders-Quality of Life (PAGI-QOL) The PAGI-QOL Is an instrument scoring 30 factors each from 0 (none of the time) to 5 (all of the time). Symptoms are assessed over a 2 week period and include the 5 domains daily activities, clothing, diet and food habits, psychological well-being/distress, and relationships.