This study is looking at whether a treatment called intermittent Theta Burst Transcranial Magnetic Stimulation (iTBS-TMS) can help people with bipolar disorder better manage their emotions. iTBS-TMS uses magnetic pulses to gently stimulate specific areas of the brain. Researchers want to see if stimulating a brain area called the inferior parietal lobule (IPL) can improve how this area connects with another important emotion regulation region (anterior insula, AI), and if this leads to better performance on tasks related to emotion regulation. You might be able to join if you are 24-65 years old, have bipolar I or II disorder, and are currently experiencing a depressive episode. The study aims to enroll 136 participants, but its current recruitment status is unclear.

Study design

This is an interventional study where participants will be randomly assigned to receive either active Transcranial Magnetic Stimulation (TMS) or a sham (placebo) TMS. The study plans to enroll 136 participants.

What's involved

Participants will receive 6 sessions of iTBS per day over 4 days, totaling 24 sessions. You will also have fMRI scans at the beginning and 3 days after the last treatment day.

Compensation

Not stated in the trial record.

Follow-up

Brain function changes will be measured at baseline and 1-3 days after the 4-day intervention, up to 4 weeks after baseline.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.