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Study on Ventilation and Eye Pressure in Children

This study is looking at how changing a child's breathing during an eye exam under anesthesia affects the pressure inside their eye (intraocular pressure or IOP). Researchers will adjust the level of carbon dioxide (CO2) in the child's breath to see how it impacts the choroid, a layer of blood vessels in the eye. This is important because changes in the choroid can affect eye pressure during surgery. The main goal is to measure the eye pressure after different CO2 levels are maintained for at least 5 minutes each. Children aged newborn to 8 years who are having an eye exam under anesthesia can participate. The study aims to enroll 20 children.

Study design
This is an interventional study involving 20 participants. It is not specified if it is randomized or blinded.
What's involved
If your child participates, their end-tidal CO2 levels will be adjusted to specific targets (40mmHg, then 30mmHg, then 50mmHg) during their eye exam under anesthesia. Eye pressure will be measured after each CO2 level is held for at least 5 minutes.
Compensation
Not stated in the trial record.
Follow-up
Eye pressure measurements will be taken during the single procedure after each ventilation manipulation. No further follow-up is specified.

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NCT06275308

Effect of Raised End-Tidal pCo2 on Choroidal Volume

Recruiting
NAUp to 8InterventionalBasic science
University of Pittsburgh
~20 participants
Updated 2026-01-09 on ClinicalTrials.gov
What's tested:Ventilation manipulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Intraocular Pressure (IOP) (mmHg)
Measured over After induction of anesthesia end tidal CO2 will be manipulated to 40mmHg, then 30mmHg and then 50mmHg. The end tidal CO2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period IOP measured

Conditions

Intraocular Pressure

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Intraocular Pressure

NCT06275308

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Amy Monroe, MPH, MBA · STUDY_DIRECTOR · University of Pittsburgh
  • Kanwal Nischal, MD,FRCOphth · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Amy Monroe, MPH, MBA
[email protected]
412-623-6382 · ext. 6382
Email the study team

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Eligibility criteria

Inclusion

any child undergoing an eye exam under anesthesia for an ophthalmologic reason.
children between the ages newborn to 8 years of age.

Exclusion

children who are not having an eye exam under anesthesia.
children with a known medical diagnosis that affect the eye to be studied
\* children over the age of 8 years of age.
\* children with altered cerebral autoregulation, increased intracranial pressure, pulmonary hypertension, or any other condition deemed appropriate by the anesthesiologist.
children in whom a laryngeal mask airway will not be used

What this trial measures

  • Intraocular Pressure (IOP) (mmHg)After induction of anesthesia end tidal CO2 will be manipulated to 40mmHg, then 30mmHg and then 50mmHg. The end tidal CO2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period IOP measured

    Measurement of intraocular pressure after maintenance of end tidal pCO2 for 5 minutes at three end tidal pCO2 values : 40mmHg, then 30mmHg and then 50mmHg