TAP Trial: Aspirin After Preeclampsia

This study, called the TAP Trial, is looking at whether low-dose aspirin (81 mg) can help women recover after experiencing preeclampsia (a serious high blood pressure condition during pregnancy). You would receive either low-dose aspirin or a placebo (an inactive pill that looks the same) daily for six months after delivery. The main goal of this pilot study is to see if it's practical to conduct a larger trial like this and to assess if aspirin helps improve blood vessel function and lower blood pressure. To join, you must be a woman between 18 and 55 years old who has recently had preeclampsia. You cannot participate if you have certain conditions like pre-pregnancy high blood pressure or diabetes, or an allergy to aspirin. The study is currently unclear about its recruitment status and plans to enroll 60 participants.

Study design
This is a pilot, randomized, double-blind study where 60 participants will be assigned by chance to receive either low-dose aspirin or a placebo. Neither you nor your doctor will know which you are receiving.
What's involved
You would take a pill daily for six months and monitor your blood pressure at home. You would also have three study visits involving blood pressure measurements, blood draws, questionnaires, and a test called microiontophoresis.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for approximately 6 months postpartum.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06281665

Treatment With Aspirin After Preeclampsia: TAP Trial

Recruiting
PHASE4Ages 18–55Interventional
Malamo Countouris
~60 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:Low-dose aspirinPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent of participants eligible, enrolled and retained (feasibility)
Measured over Baseline to approximately 6 months postpartum
Hypertensive Disorder of Pregnancy
Pre-Eclampsia
Hypertension
Eclampsia
Gestational Hypertension
Cardiovascular Diseases
Toxemia
Pregnancy Complications
Vascular Diseases
Hypertension, Pregnancy Induced
Hypertension;Pre-Eclamptic
1 sites across 1 states
Pennsylvania1
  • Alisse K Hauspurg, MD · PRINCIPAL_INVESTIGATOR · UPMC Magee Women's Hospital

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Postpartum individuals ≥18 years old
Preeclampsia diagnosis

Exclusion

Fetal anomaly
Multiple gestation
Pre-pregnancy hypertension
Allergy or contraindication to low-dose aspirin
Pre-pregnancy diabetes
  • Percent of participants eligible, enrolled and retained (feasibility)Baseline to approximately 6 months postpartum

    To determine the feasibility of conducting a single-site randomized controlled trial of 6 months of postpartum low-dose aspirin vs. placebo in women with preeclampsia.