This study, called the RECSUR-study, is looking at the best ways to treat glioblastoma (a type of brain cancer) when it comes back. Researchers want to compare tumor removal surgery (re-resection) with other standard treatments like Temozolomide (chemotherapy), Lomustine (another chemotherapy), re-irradiation (radiation therapy), or experimental therapies such as oncolytic virotherapy or immunotherapy. The goal is to see which approach leads to better overall survival (how long patients live) and to understand any neurological problems (like issues with movement or speech) that might happen after 6 weeks. You might be able to join if you are between 18 and 90 years old, have recurrent glioblastoma that can be surgically removed, and provide your consent. This is an observational study, meaning researchers will watch and learn from patients receiving these treatments.

Study design

This is an international, multi-center, prospective observational study involving 464 participants. Patients will either have surgery to remove the tumor or receive other standard treatments, with decisions made by a tumor board.

What's involved

If you participate, you will undergo evaluation at the start of the study, and then at 6 weeks, 3 months, and 6 months after treatment. These evaluations will include tests for motor, language, and cognitive function, as well as overall patient functioning.

Compensation

Not stated in the trial record.

Follow-up

Your overall survival will be measured for up to 5 years after surgery. Neurological problems will be assessed at 6 weeks post-surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.