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Ketamine for Pain During Minor Procedures

This study is looking at whether intranasal ketamine can help reduce pain during minor procedures in the emergency department (ED). If you are between 7 and 70 years old, weigh less than 115kg, and need a minor procedure in the ED, you might be able to join. Participants will receive either intranasal ketamine or intranasal saline (saltwater solution) in addition to the usual local anesthesia (numbing medicine). Researchers want to see if those who receive ketamine report lower pain scores at 15, 30, and 60 minutes after the procedure. This study aims to find better ways to manage pain during common ED procedures.

Study design
This is a double-blind, randomized controlled study involving 108 participants. This means neither you nor your doctor will know if you are receiving ketamine or saline, and participants are assigned to groups by chance.
What's involved
You would receive either intranasal ketamine or intranasal saline, along with standard local anesthesia, during your minor ED procedure.
Compensation
Not stated in the trial record.
Follow-up
Your pain levels will be measured at 15, 30, and 60 minutes after the procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06284473

Ketamine as a Supplement to Local Anesthesia for Minor Procedures

Recruiting
PHASE4Ages 7–70InterventionalTreatment
Loyola University
~108 participants
Updated 2025-10-03 on ClinicalTrials.gov
What's tested:KetamineSaline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Immediate pain
Measured over 15 minutes
+2 more outcomes measured

Conditions

Pain, Procedural
Minor Laceration
Abscess

Explore related trials

AbscessMinor lacerationPain

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Trent Reed, DO · PRINCIPAL_INVESTIGATOR · Loyola University

Who to contact

Shannon Lovett, MD
[email protected]
708-327-2549
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Undergoing Minor Procedure in the ED
Weight not to exceed 115kg

Exclusion

Altered Mental Status
Pregnancy
Breastfeeding
Acute head or eye injury
Intercranial Hypertension
Hx of seizures
Hx of chronic pain
Unstable vital signs
Allergy to Ketamine
Hepatic or Renal Insufficiency
Hx of Psychiatric Illness
Hx of alcohol/drug abuse

What this trial measures

  • Immediate pain15 minutes

    Pain will be measured using the numeric rating scale which is a scale ranging from 0 to 100, where higher values report greater pain

  • Acute pain30 minutes

    Pain will be measured using the numeric rating scale which is a scale ranging from 0 to 100, where higher values report greater pain

  • Delayed pain60 minutes

    Pain will be measured using the numeric rating scale which is a scale ranging from 0 to 100, where higher values report greater pain