Personalized Transcranial Direct Current Stimulation in Stroke Recovery

This study is looking at how personalized transcranial direct current stimulation (tDCS) with occupational therapy (OT) might help people recover after a stroke. tDCS uses a weak electrical current applied to your head. Researchers want to see if this treatment can improve how different parts of your brain connect, which could lead to lasting improvements in your recovery. You might be able to join if you are between 18 and 80 years old, had an ischemic or hemorrhagic stroke more than three months ago, and have some weakness in one side of your body. The main goal is to measure changes in brain connectivity using a special brain scan (fMRI) at the beginning and after four weeks of treatment. The study status is currently unclear.

Study design
This is a randomized, sham-controlled, double-blind study with 80 participants. This means participants will be randomly assigned to receive either the active tDCS or a sham (inactive) treatment, and neither you nor the researchers will know which one you are receiving.
What's involved
You would receive 10 treatment sessions of either active tDCS or sham tDCS, each lasting 20 minutes during occupational therapy. You will also have fMRI brain scans at the beginning and after four weeks.
Compensation
Not stated in the trial record.
Follow-up
Your brain connectivity will be measured at baseline and again after 4 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06286800

Personalized Transcranial Direct Current Stimulation in Stroke Recovery

Recruiting
NAAges 18–80InterventionalTreatment
The Methodist Hospital Research Institute
~80 participants
Updated 2026-03-02 on ClinicalTrials.gov
What's tested:Transcranial direct current stimulation (tDCS) with OTSham tDCS with OT

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
fMRI functional connectivity biomarker
Measured over baseline and 4 weeks
Stroke
Chronic Stroke
Hemorrhage Brain
Ischemic Stroke
1 sites across 1 states
Texas1
  • Timea Hodics, MD · PRINCIPAL_INVESTIGATOR · The Methodist Hospital Research Institute

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Symptomatic ischemic or hemorrhagic stroke verified by computerized axial tomography or magnetic resonance imaging resulting in hemiparesis (MRC 1-4).
Age more than 18, Male or Female, All racial and ethnic groups
Entry into the study \>3 months post onset
Modified Ashworth Scale Score \<3 in the involved upper extremity
Passive range of motion within functional ranges at the shoulder, elbow, wrist and hand
Able to follow 2 step commands

Exclusion

Patients with history of severe alcohol or drug abuse, psychiatric illnesses like severe depression, poor motivational capacity, or severe language disturbances, particularly of receptive nature or with serious cognitive deficits (defined as unable to follow study instructions).
Patients with bilateral paresis, or weakness or sensory damage due to peripheral causes (e.g. peripheral nerve injury, muscle or orthopedic injury etc.)
Patients with severe uncontrolled medical problems (e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age,epilepsy or others).
Patients with unstable cardiac arrhythmia.
Pregnancy
Patients with metallic implants in the head, patients with pacemakers, patients with craniotomies, including burr holes who cannot be safely stimulated
Patients with seizures
Non-English speaking individuals will only be eligible if they can provide the appropriate translator for all the sessions of the study as no funding is available to pay for such services.
  • fMRI functional connectivity biomarkerbaseline and 4 weeks

    Task activation, resting state functional connectivity