This study, called CLIMB II, is looking at how different lengths of intestine used in Roux-en-Y Gastric Bypass (RYGB) surgery affect weight loss. Specifically, it compares a standard approach with fixed limb lengths to a new approach where the limb lengths are adjusted based on your total small bowel length. The goal is to see if these adjusted lengths lead to more weight loss and better improvement in conditions like diabetes and high blood pressure. You might be able to join if you are 18 to 70 years old, have morbid obesity (a BMI between 40 and 60), and agree to long-term follow-up. The study aims to enroll 262 participants to see if the adjusted limb lengths lead to better outcomes.

Study design

This is a randomized controlled trial, meaning participants will be randomly assigned to one of two surgery groups. The study plans to enroll 262 participants.

What's involved

You would undergo Roux-en-Y Gastric Bypass surgery. Routine follow-up visits in the Bariatric clinic will occur every 6 months for the first two years, then yearly after that.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 6, 12, 24, and 60 months after surgery to measure changes in total weight loss.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.