Back to search results

Trauma-Informed Guilt Reduction Therapy for Veterans with PTSD

This study is comparing two behavioral therapies for U.S. Veterans who have post-traumatic stress disorder (PTSD) and trauma-related guilt. The therapies are Trauma-Informed Guilt Reduction (TrIGR) Therapy and Prolonged Exposure (PE) Therapy. Researchers want to see if TrIGR Therapy is as effective as PE Therapy in reducing PTSD symptoms, improving daily functioning, and decreasing depression. They also want to see if TrIGR Therapy is better at reducing trauma-related guilt and shame. You may be able to join if you are a Veteran aged 18 or older who served since Operation Enduring Freedom/Operation Iraqi Freedom, have PTSD, and experience significant trauma-related guilt. The study aims to enroll 158 participants, but its current status is unclear.

Study design
This is an interventional study comparing two different behavioral therapies. It plans to enroll 158 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptoms will be measured at the start of the study, and then 8, 16, and 28 weeks after your first therapy session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06296589

Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

Recruiting
NAAges 18+InterventionalTreatment
Veterans Medical Research Foundation
~158 participants
Updated 2026-08-25 on ClinicalTrials.gov
What's tested:Trauma Informed Guilt Reduction TherapyProlonged Exposure Therapy

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinician Administered PTSD Scale for DSM-5 (CAPS-5)
Measured over baseline and 8-, 16-, and 28 weeks after the first therapy session

Conditions

Stress Disorders, Post-Traumatic

Explore related trials

Post-Traumatic Stress Disorder

Where it's being run

4 sites across 4 states
Arkansas1
California1
Louisiana1
Wisconsin1

Study leadership

  • Shannon Kehle-Forbes, PhD · PRINCIPAL_INVESTIGATOR · University of Minnesota

Who to contact

Sonya Norman, PhD
[email protected]
858-518-8266
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

U.S. Veterans age 18 or older who served in the military since the start of Operation Enduring Freedom/Operation Iraqi Freedom; OEF/OIF)
meets diagnostic criteria for PTSD;
a score of 2 or higher ("true" to "extremely true") on feeling trauma-related guilt much or all of the time or scoring 3 or higher ("very true" or "extremely true") on at least one guilt cognition factor (hindsight bias/responsibility, wrongdoing, or lack of justification) on the Trauma Related Guilt Inventory
not currently receiving trauma-focused treatment such as PE or CPT
willingness to attend psychotherapy and assessment sessions

Exclusion

current risk of suicidal/homicidal behavior that requires immediate intervention
current severe substance use disorder (in the past two months) based on DSM-5 criteria
current unmanaged psychosis or mania
life threatening or unstable medical illness
inability to read

What this trial measures

  • Clinician Administered PTSD Scale for DSM-5 (CAPS-5)baseline and 8-, 16-, and 28 weeks after the first therapy session

    Measures PTSD symptom severity, score range 0-80, higher scores mean greater symptom severity