AML and Leukemia Stem Cell Markers (CLL1 and CD45RA) Study

This study is for people diagnosed with Acute Myeloid Leukemia (AML), a type of blood cancer. Researchers are looking at specific markers called CLL1 and CD45RA on certain blood cells (hematopoietic stem cells) during your initial AML treatment. They will measure the percentage of these cells on days 3, 5, and 7 of your therapy. The goal is to see if these markers can predict how well you respond to treatment after six weeks. This could help doctors choose the best treatments for AML patients more quickly, potentially avoiding invasive bone marrow biopsies. You can join if you are 18 or older, have AML, can receive treatment at the research center, and have elevated levels of CLL1A and CD45RA positive cells at diagnosis.

Study design
This is an observational study with a planned enrollment of 20 participants. It is not a drug trial but rather looks at specific markers in your blood.
What's involved
You would have blood samples taken on days 3, 5, and 7 during your initial AML treatment to measure specific cell markers.
Compensation
Not stated in the trial record.
Follow-up
Researchers will assess your treatment response at 6 weeks.

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NCT06297551

Acute Myeloid Leukemia and Markers of Leukemia Stem Cells (CLL1 and CD45RA)

Recruiting
Not specifiedAges 18+Observational
Suhu Liu
~20 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:Quantification of blood cells positive for CLL1 and CD45RA surface markers by flow cytometry

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Concordance between the relative fraction of Leukemia Stem Cells (LSC) vs Hematopoietic Stem Cells (HSC) and treatment response
Measured over 6 weeks
Acute Myeloid Leukemia
1 sites across 1 states
New York1
  • Suhu Liu, MD PhD · PRINCIPAL_INVESTIGATOR · Stony Brook Medicine

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

diagnosis of acute myeloid leukemia
ability to receive treatment for acute myeloid leukemia at the research center
elevated values of CLL1A and CD45RA positive cells at the time of diagnosis
  • Concordance between the relative fraction of Leukemia Stem Cells (LSC) vs Hematopoietic Stem Cells (HSC) and treatment response6 weeks