Deep Brain Stimulation for Speech and Arm Function After Stroke
This study is looking at whether Deep Brain Stimulation (DBS) of the Motor Thalamus can help improve speech and arm/hand movement for people who have had a stroke. Participants will have a surgical procedure to place small wires (electrodes) in their brain, which will be connected to external stimulators. Researchers will then test how these stimulators affect your arm, hand, and speech. The goal is to see if this treatment can help restore these functions. You may be able to join if you are 18-75 years old, had a single stroke more than 6 months ago that caused speech difficulties (dysarthria), and speak English. The study aims to see if this treatment can reduce problems like adverse events, discomfort, and pain.
- Study design
- This is an interventional study planning to enroll 10 participants. It is designed to assess the immediate and long-lasting effects of Deep Brain Stimulation.
- What's involved
- You will undergo a surgical procedure to implant electrodes, which will be connected to external stimulators. Experiments will be performed to test movements and speech, and the implant will be removed after less than 30 days.
- Compensation
- Not stated in the trial record.
- Follow-up
- Adverse events will be measured at 29 days. Discomfort and pain will be measured at baseline, 2 weeks, 4 weeks, and 6 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke
At a glance
Conditions
NCT06303869
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Pittsburgh
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jorge Gonzalez-Martinez, MD/PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Adverse Events29 days
The investigators will quantify the safety of DBS to treat post-stroke speech and upper-limb motor deficits. For this, the investigators will record all adverse events for the entire study duration. The study is considered successful if no serious adverse events related to the use of deep brain stimulation are reported.
- Discomfort and PainBaseline, 2 weeks, 4 weeks, 6 months.
The investigators will assess the relative level of discomfort and/or pain that is associated with the delivery of electrical stimulation to the motor thalamus. After each stimulation train patients will be asked to report a level of perceived discomfort using a 10 value subjective scale. Low values will be assigned to low discomfort and high values to high discomfort. The study is considered successful if 70% of recruited subjects do not report discomfort or pain at stimulation amplitudes that are required to obtain motor responses in the face and upper-limb muscles.