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Observational Study of Gastric Motor Dysfunction in Gastric Antral Vascular Ectasia

This study is looking into Gastric Antral Vascular Ectasia (GAVE), a condition where blood vessels in the stomach enlarge and can bleed, causing symptoms like stomach pain and nausea. Researchers want to understand how often these symptoms occur and how they relate to how well your stomach functions. You would participate by taking a non-radioactive, non-invasive breath test called the 13C-Spirulina GEBT at home, with help from the study team. This study is for adults aged 19 and older who have GAVE confirmed by an endoscopy. The study aims to measure your symptoms using questionnaires like the Nepean Dyspepsia Index, Abridged Bowel Disease Questionnaire, and Leuven Postprandial Distress Scale at the start of the study. The current recruitment status is unclear, and they plan to enroll 30 participants.

Study design
This is an observational study involving 30 participants. It is not a treatment study but aims to gather information about Gastric Antral Vascular Ectasia.
What's involved
You would complete a 13C-Spirulina GEBT breath test at home, with remote assistance. You would also complete questionnaires about your symptoms at the beginning of the study.
Compensation
Not stated in the trial record.
Follow-up
Your symptoms will be measured at baseline (the start of the study).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06306963

Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

Recruiting
Not specifiedAges 19+Observational
Mayo Clinic
~30 participants
Updated 2026-03-04 on ClinicalTrials.gov
What's tested:Gastric Emptying Breath Test

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Nepean Dyspepsia Index
Measured over baseline
+3 more outcomes measured

Conditions

Gastric Antral Vascular Ectasia
Cirrhosis
Chronic Kidney Disease

Explore related trials

Chronic Kidney DiseaseCirrhosisGastric Antral Vascular Ectasia

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Xiao Jing Wang, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Taylor N Hines
[email protected]
507-538-9959
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients \>18 years of age with endoscopic evidence of Gastric Antral Vascular Ectasia.
Willingness to participate in the study
Capacity to provide informed consent.
No evidence of organic, systemic, or metabolic disease (e.g. diabetes mellitus) to explain the symptoms on routine investigations

Exclusion

Patients with transfusion dependent blood loss.
Patients with severe decompensated liver disease.
Patients with end stage renal disease.
Presence of other diseases (structural or metabolic) which could interfere with interpretation of the study results.
Pregnant or lactating women.
Patients who have not had a CBC and differential blood draw completed within the last six months.
Current heavy alcohol use.

What this trial measures

  • Nepean Dyspepsia Indexbaseline

    The Nepean Dyspepsia Index is a 10-item questionnaire that measures dyspepsia problems. Each item is scored from 1-5. 1 = Not at all, 5 = Extremely. Total scores range from 10 - 50, lower scores indicate less dyspepsia problems, higher scores indicate more dyspepsia problems.

  • Abridged Bowel Disease Questionnairebaseline

    The Abridged Bowel Disease Questionnaire is a 14-item questionnaire that measures Bowel Disease symptoms. Each item is scored as yes or no. Scores answering yes indicate more bowel disease, and scores answering no indicate less or no bowel disease.

  • Leuven Postprandial Distress Scalebaseline

    The Leuven Postprandial Distress Scale is an 8-item questionnaire that measures symptoms of dyspepsia. Each item is scored from 1-5. 1 = Absent, 5 = very severe. Total scores range from 0-40 Lower scores indicate less or no symptoms of dyspepsia, higher scores indicate more symptoms of dyspepsia.

  • Bowel Disease Screen QuestionnaireBaseline

    the Bowel Disease Screen Questionnaire is a 20 item questionnaire that measures stomach and bowel disease symptoms. Each item is scored from 1-5. 1=not at all, 5=Extremely. Total scores range from 10-95.