Couples Motivational Interviewing for Drug Use and HIV Risk

This study is looking at an intervention called "Couples Health Project" to help male couples reduce drug use and lower their risk of HIV. This intervention uses couples motivational interviewing, a type of counseling. Researchers want to see if this approach is more effective than standard couples HIV testing and counseling. They will measure how often participants use drugs, check urine for drug use, and look at risky sexual behaviors with casual partners after 9 months. To join, you must be a man between 18 and 55 years old, in a relationship with another cisgender male for at least 3 months. One partner must be HIV-negative, and one must have used at least one drug (like cocaine, opiates, or misused prescription drugs) in the last 30 days. The study aims to enroll 360 couples, but its current recruitment status is unclear.

Study design
This study is an interventional trial with a randomized controlled design, meaning participants will be randomly assigned to one of two groups. It plans to enroll 360 participants.
What's involved
The Couples Health Project intervention involves 3 counseling sessions. The study measures drug use and sexual behaviors at 9 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for at least 9 months to assess drug use and sexual behaviors.

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NCT06307977

Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples

Recruiting
NAAges 18–55InterventionalHealth services
Hunter College of City University of New York
~360 participants
Updated 2025-06-13 on ClinicalTrials.gov
What's tested:Couples Health Project

At a glance

Recruiting sites
1 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Drug use Frequency
Measured over 9 Months
+2 more outcomes measured
Substance Use
HIV Infections
3 sites across 3 states
Michigan1
New York1
Virginia1

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Eligibility criteria

Inclusion

Have a main partner who is another cisgender male and have been in a relationship for 3 month or longer
Index participant must be between 18 and 55; Main partner can be any age 18 and older
One participant must be HIV negative (as confirmed by rapid test)
One participant must have used at least 1 drug in the past 30 days (cocaine/crack, opiates, misuse of prescription medication, stimulants, psychedelics, ecstasy, ketamine, GHB, amyl nitrite)
Index participant must have engaged in TRB in the past 30 days- Defined as CAS with a casual partner, or a serodiscordant or non-monogamous main partner
Live in the United States
Speak and read English

Exclusion

Any signs of serious mental illness or cognitive deficit
Current suicidal/homicidal ideations
History of IPV with their main partner and safety concerns in the current relationship.
  • Drug use Frequency9 Months

    Number of reported days of illicit drug use (amphetamines, cocaine/crack, GHB, ketamine or ecstasy) reported on quarterly timeline follow-back assessments

  • Urine assay for drug use9 Months

    Positive urine screen for drug use assessed bi-annually

  • CAS with casual partners9 Months

    Number of total anal sex acts (insertive and receptive) with casual partners reported on quarterly timeline follow-back assessments in the absence of adequate PrEP coverage