Evaluating Topical Imipramine and Amitriptyline for Rosacea Redness
This study is looking at whether topical (applied to the skin) imipramine or amitriptyline can reduce redness caused by ultraviolet B light in people with rosacea. Rosacea is a common skin condition that causes easy blushing and facial redness, often made worse by sunlight. Researchers will compare how well 4% imipramine and 4% amitriptyline reduce redness compared to a vehicle (a cream or liquid without active medicine). They will measure redness at 10, 60, and 120 minutes after treatment. You may be able to join if you are an adult with rosacea or a control subject without a history of flushing/blushing, and have Fitzpatrick Skin Type I-IIII. The study aims to enroll 48 participants, but its current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 48 participants. It will compare the effects of 4% imipramine, 4% amitriptyline, and a vehicle (0.1ml propylene glycol).
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Redness will be measured up to 120 minutes after treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Difference in redness of Ultraviolet B induced erythema with 4% imipramine10 minutes post-treatment
Erythema change from baseline with 4% imipramine application in response to a low level of UVB are measured by using a mexameter device and thermal photography.
- Difference in redness of Ultraviolet B induced erythema with 4% imipramine60 minutes post-treatment
Erythema change from baseline with 4% imipramine application in response to a low level of UVB are measured by using a mexameter device and thermal photography.
- Difference in redness of Ultraviolet B induced erythema with 4% imipramine120 minutes post-treatment
Erythema change from baseline with 4% imipramine application in response to a low level of UVB are measured by using a mexameter device and thermal photography.
- Difference in redness of Ultraviolet B induced erythema with 4% imipramine24 hours post-treatment
Erythema change from baseline with 4% imipramine application in response to a low level of UVB are measured by using a mexameter device and thermal photography.
- Difference in redness of Ultraviolet B induced erythema with 4% amitriptyline10 minutes post-treatment
Erythema change from baseline with 4% amitriptyline application in response to a low level of UVB are measured by using a mexameter device and thermal photography.
- Difference in redness of Ultraviolet B induced erythema with 4% amitriptyline60 minutes post-treatment
Erythema change from baseline with 4% amitriptyline application in response to a low level of UVB are measured by using a mexameter device and thermal photography.
- Difference in redness of Ultraviolet B induced erythema with 4% amitriptyline120 minutes post-treatment
Erythema change from baseline with 4% amitriptyline application in response to a low level of UVB are measured by using a mexameter device and thermal photography.
- Difference in redness of Ultraviolet B induced erythema with 4% amitriptyline24 hours post-treatment
Erythema change from baseline with 4% amitriptyline application in response to a low level of UVB are measured by using a mexameter device and thermal photography.