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Seattle STRIDE Study for Inflammatory Bowel Disease

This observational study, called Seattle STRIDE, is looking for children and young adults aged 6 to 21 years old who have suspected Inflammatory Bowel Disease (IBD), including Crohn's Disease, Ulcerative Colitis, or Indeterminate Colitis. It also includes a group of patients with functional abdominal pain who do not have gut inflammation. The study aims to collect long-term clinical information and samples, such as blood, stool, and tissue from procedures like Esophagogastroduodenoscopy (EGD) and Colonoscopy with biopsy, to better understand IBD. The main goal is to collect these samples for future research using a special technique called spatial transcriptomics. The study status is currently unclear, but it plans to enroll 200 participants.

Study design
This is an observational study that plans to enroll 200 participants. It is not a treatment study, but rather collects information and samples during regular clinical visits.
What's involved
You would have blood, stool, and tissue samples collected during your regular clinical visits. You will also be asked to provide urine samples specifically for research.
Compensation
Not stated in the trial record.
Follow-up
Samples will be collected for spatial transcriptomics research over a period of 3 years.

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NCT06315179

Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)

Recruiting
Not specifiedAges 6–21Observational
Seattle Children's Hospital
~200 participants
Updated 2026-04-24 on ClinicalTrials.gov
What's tested:Esophagogastroduodenoscopy (EGD) with biopsyColonoscopy w/ biopsy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Bio-repository sample collection for spatial transcriptomics
Measured over 3 years

Conditions

Inflammatory Bowel Diseases
Crohn Disease
Ulcerative Colitis
Indeterminate Colitis
Functional Abdominal Pain Syndrome
Functional Bowel Disorder
Esophageal Diseases
Gastroduodenal Disorder
Bowel Dysfunction
Gallbladder Diseases
Sphincter of Oddi Dysfunction
Anorectal Disorder

Explore related trials

Anorectal disorderBowel dysfunctionColitis of Indeterminate TypeCrohn DiseaseDisorders of the Brain-Gut InteractionsDysfunction of sphincter of OddiEsophageal DisorderFunctional abdominal pain syndromeFunctional belching disorderGallbladder DisorderGastroduodenal disorderInflammatory Bowel DiseaseUlcerative Colitis

Where it's being run

1 sites across 1 states
Washington1

Study leadership

  • Betty (Hengqi) Zheng, MD · PRINCIPAL_INVESTIGATOR · Seattle Children's Hospital, University of Washington

Who to contact

Mason E Nuding, BS
[email protected]
206-987-0055
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Suspected diagnosis of CD (Crohn's Disease), UC (Ulcerative Colitis) or Indeterminate colitis (IC)

Exclusion

Evidence of Other Complicating Medical Issues:
Other serious medical conditions, such as neurological, liver, kidney, or systemic disease
Pregnancy
Tobacco, alcohol, or illicit drug abuse

What this trial measures

  • Bio-repository sample collection for spatial transcriptomics3 years

    Collection of blood and stool samples at baseline month 1, month 2, month 3, month 6, month 12, month 24, and month 36. Tissue will be collected at baseline and at any follow-up endoscopy or surgical intervention.