Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

This study is looking at how the order of eating different diets affects body fat. Researchers want to see if starting with a low-carbohydrate diet (15% protein, 75% fat, 10% carbohydrate) or a low-fat diet (15% protein, 10% fat, 75% carbohydrate) first makes a difference in fat loss. You would follow one diet for 4 weeks, then switch to the other for another 4 weeks. The main goal is to measure changes in your total body fat mass after 8 weeks. This study is for adults aged 18 to 50 who are overweight or have obesity (Body Mass Index or BMI of 25 or higher). The current status of this study is unclear, and it plans to enroll 42 participants.

Study design
This is an interventional study with 42 planned participants, comparing the effects of a low-carbohydrate diet and a low-fat diet given in different orders.
What's involved
You would follow a specific diet for 4 weeks, then switch to another diet for another 4 weeks, for a total of 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your body fat will be measured at the beginning and again at 8 weeks.

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NCT06325722

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

Recruiting
NAAges 18–50InterventionalBasic science
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
~42 participants
Updated 2026-07-31 on ClinicalTrials.gov
What's tested:Low-carbohydrate DietLow-fat Diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in total fat mass
Measured over 8 weeks
Overweight
Obesity
1 sites across 1 states
Maryland1
  • Valerie L Darcey · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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  • Change in total fat mass8 weeks

    Change in total fat mass (kg) as measured by dual energy X-ray absorptiometry (DXA) from baseline to week 8