Study on Transplanting Lungs from Uncontrolled Donation After Circulatory Death

This study is exploring a new way to make more lungs available for transplant. Researchers have developed a special method called the "Lung uDCD Protocol" that uses positive end expiratory pressure (PEEP) and extra oxygen to preserve lungs for about three hours after a person has died. This method could allow for organ donation in situations where it wasn't possible before. The study aims to see how safe and effective this protocol is by looking at how well the lungs are preserved, how many are successfully transplanted, and if there are any issues like severe primary graft dysfunction (PGD Grade III) within 72 hours after transplant. You might be able to join if you are an adult waiting for a lung transplant and are willing to participate in the research. The study plans to enroll 24 participants.

Study design
This is an interventional study with a planned enrollment of 24 participants. It is not specified if it is randomized or blinded.
What's involved
You would need to be willing to participate in the research study. The record does not describe specific visits, procedures, or tests you would undergo.
Compensation
Not stated in the trial record.
Follow-up
You must be able to be followed for 1 year after transplantation.

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NCT06327945

Transplanting Lungs From Uncontrolled Donation After Circulatory Death

Recruiting
NAAges 18+Interventional
NYU Langone Health
~24 participants
Updated 2025-02-28 on ClinicalTrials.gov
What's tested:Lung uDCD Protocol

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Primary Graft Dysfunction (PDG) Grade III
Measured over 72 Hours Post-Transplant
Lung Transplantation
1 sites across 1 states
New York1
  • Stephen Wall, MD · PRINCIPAL_INVESTIGATOR · NYU Langone Health

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Eligibility criteria

Inclusion

Patients waiting for lung transplants
Willing to participate in the research study

Exclusion

Unable to be followed for 1 year after transplantation
Unable to provide written informed consent to participate in the research (or designate a surrogate)
  • Incidence of Primary Graft Dysfunction (PDG) Grade III72 Hours Post-Transplant

    PGD is measured 72 hours after transplantation and defined according to the International Society for Heart and Lung Transplantation (ISHLT) criteria: partial pressure of arterial oxygen divided by the fraction of inspired oxygen (Pa02/FI02) \< 200 mm Hg.