Study on Transplanting Lungs from Uncontrolled Donation After Circulatory Death
This study is exploring a new way to make more lungs available for transplant. Researchers have developed a special method called the "Lung uDCD Protocol" that uses positive end expiratory pressure (PEEP) and extra oxygen to preserve lungs for about three hours after a person has died. This method could allow for organ donation in situations where it wasn't possible before. The study aims to see how safe and effective this protocol is by looking at how well the lungs are preserved, how many are successfully transplanted, and if there are any issues like severe primary graft dysfunction (PGD Grade III) within 72 hours after transplant. You might be able to join if you are an adult waiting for a lung transplant and are willing to participate in the research. The study plans to enroll 24 participants.
- Study design
- This is an interventional study with a planned enrollment of 24 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would need to be willing to participate in the research study. The record does not describe specific visits, procedures, or tests you would undergo.
- Compensation
- Not stated in the trial record.
- Follow-up
- You must be able to be followed for 1 year after transplantation.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Transplanting Lungs From Uncontrolled Donation After Circulatory Death
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Stephen Wall, MD · PRINCIPAL_INVESTIGATOR · NYU Langone Health
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Incidence of Primary Graft Dysfunction (PDG) Grade III72 Hours Post-Transplant
PGD is measured 72 hours after transplantation and defined according to the International Society for Heart and Lung Transplantation (ISHLT) criteria: partial pressure of arterial oxygen divided by the fraction of inspired oxygen (Pa02/FI02) \< 200 mm Hg.