Back to search results

Radiation Therapy for Dupuytren's Contracture

This study is looking into whether radiation therapy can help prevent Dupuytren's Contracture (a condition where tissue under the skin of the palm thickens, causing fingers to bend) from returning after treatment. Participants will first receive an injection of Collagenase Clostridium Histolyticum to help release the contracture. Then, they will have two 5-day courses of radiation therapy, separated by 6-8 weeks. Researchers will follow participants for three years to see if the contracture comes back. You may be able to join if you are 45 or older, have Dupuytren's Contracture with a finger bend of more than 10 degrees, and cannot lay your hand flat on a table. The study aims to enroll 95 people.

Study design
This is a prospective phase II trial involving 95 participants. It is a single-arm study where all participants receive the same treatment.
What's involved
You will receive a Collagenase Clostridium Histolyticum injection and release, followed by two 5-day courses of radiation therapy. You will then be followed for 3 years for recurrence.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for recurrence of Dupuytren's Contracture for 36 months (3 years) after radiation treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06330545

Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Recruiting
NAAges 45+InterventionalPrevention
Dartmouth-Hitchcock Medical Center
~95 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:Radiation therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Recurrence of Dupuytren's Contracture
Measured over one month, 6 months, 12 months, 24 months, and 36 months post-radiation treatment

Conditions

Dupuytren Contracture

Explore related trials

Palmar Fibromatosis

NCT06330545

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Dartmouth Hitchcock

    Lebanon, New Hampshirestudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Lance Warhold, MD · PRINCIPAL_INVESTIGATOR · Dartmouth Health

Who to contact

Peter A DePalo, BS, CCRP
[email protected]
603 653-0494
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age 45 or greater with DC
Extension deficit \>10 degrees
Unable to simultaneously place the affected finger and palm flat on a table.
Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included

Exclusion

Unsuccessful non-surgical release (\> N/1 disease)
They develop an open wound during CCH
Breast feeding or pregnancy
A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
Less than the age of 45
They have previously undergone radiation on the hand in which they plan to get CCH injections
They are pregnant women, impaired adults or prisoners

What this trial measures

  • Recurrence of Dupuytren's Contractureone month, 6 months, 12 months, 24 months, and 36 months post-radiation treatment

    Recurrence defined as \> 20 degrees worsening of contracture relative to within 14 days from CCH injection or the need for medical/surgical intervention to correct the new or worsening symptomatic contracture. The investigators will measure the contracture using the table top test in which patients their press hand with best of their ability. We will use a goniometer on dorsal surface of hand while performing table top test to measure PIP and MCP joints.