Paced Heart Rate Acceleration for Heart Failure
This study is testing a new approach called "Exercise-similar cardiac pacing" for people with systolic heart failure. This involves using your existing implanted cardioverter defibrillator (a device that helps regulate your heartbeat) to mimic the heart rate changes that happen during exercise. The study compares this pacing to a "Sham cardiac pacing" where the device settings are changed but no actual pacing happens. To join, you need to be 18 or older, have heart failure with a left ventricular ejection fraction (a measure of how well your heart pumps blood) of 40% or less, and be in NYHA class II-III (meaning you have some limitations due to heart failure symptoms). The main goal is to see if this pacing can improve your heart's pumping ability (left ventricular ejection fraction) over time. The study is currently unclear on its recruitment status.
- Study design
- This is a randomized, controlled study with 52 participants, where you would be assigned by computer to either the pacing or sham group. You would not know which group you are in, but the researchers would.
- What's involved
- You would undergo baseline testing, then receive either pacing or sham intervention regularly over a 6-week period. You would have follow-up tests at 2, 4, and 6 weeks during the intervention, and then at 3 and 12 months after it finishes.
- Compensation
- Not stated in the trial record.
- Follow-up
- You would be followed for 12 months after the 6-week intervention period ends.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Paced Heart Rate Acceleration for Cardiac Conditioning
At a glance
Conditions
NCT06332391
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Iowa Hospitals and Clinics
Iowa City, Iowastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Denice Hodgson-Zingman, MD · PRINCIPAL_INVESTIGATOR · University of Iowa
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Change in left ventricular ejection fraction by echocardiogramat baseline versus 2 weeks, 4 weeks, 6 weeks from start of intervention/sham and at 3 months and 12 months after completion of intervention vs. sham.
The change in left ventricular ejection fraction from baseline as determined by echocardiography