Paced Heart Rate Acceleration for Heart Failure

This study is testing a new approach called "Exercise-similar cardiac pacing" for people with systolic heart failure. This involves using your existing implanted cardioverter defibrillator (a device that helps regulate your heartbeat) to mimic the heart rate changes that happen during exercise. The study compares this pacing to a "Sham cardiac pacing" where the device settings are changed but no actual pacing happens. To join, you need to be 18 or older, have heart failure with a left ventricular ejection fraction (a measure of how well your heart pumps blood) of 40% or less, and be in NYHA class II-III (meaning you have some limitations due to heart failure symptoms). The main goal is to see if this pacing can improve your heart's pumping ability (left ventricular ejection fraction) over time. The study is currently unclear on its recruitment status.

Study design
This is a randomized, controlled study with 52 participants, where you would be assigned by computer to either the pacing or sham group. You would not know which group you are in, but the researchers would.
What's involved
You would undergo baseline testing, then receive either pacing or sham intervention regularly over a 6-week period. You would have follow-up tests at 2, 4, and 6 weeks during the intervention, and then at 3 and 12 months after it finishes.
Compensation
Not stated in the trial record.
Follow-up
You would be followed for 12 months after the 6-week intervention period ends.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06332391

Paced Heart Rate Acceleration for Cardiac Conditioning

Recruiting
NAAges 18+InterventionalTreatment
Denice Hodgson-Zingman, MD
~52 participants
Updated 2026-06-25 on ClinicalTrials.gov
What's tested:Exercise-similar cardiac pacingSham cardiac pacing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in left ventricular ejection fraction by echocardiogram
Measured over at baseline versus 2 weeks, 4 weeks, 6 weeks from start of intervention/sham and at 3 months and 12 months after completion of intervention vs. sham.
Heart Failure, Systolic

NCT06332391

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Denice Hodgson-Zingman, MD · PRINCIPAL_INVESTIGATOR · University of Iowa

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Eligibility criteria

Inclusion

Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female sex
Age 18 years or greater
Available transportation for study visits
Left ventricular ejection fraction \< or = 40% despite at least 3 months guideline-directed medial therapy
NYHA class II-III heart failure symptoms
Atrial-lead inclusive implantable cardioverter defibrillator or biventricular defibrillator in place \> 3 months
Intrinsic or biventricular paced QRS duration of \<= 120 milliseconds

Exclusion

Age \< 18 years
Inability to ambulate safely
Congenital or primary valve disease
Ongoing (not suppressed) atrial arrhythmias
Left ventricular thrombus
Severe peripheral arterial disease that limits mobility
Hospital admission for life-threatening condition (e.g. heart failure, stroke) in the past 3 months
Major surgery in the past 3 months or anticipated during the period of study
Ventricular pacing indication in the absence of biventricular pacing
Life expectancy \< 1 year
Hemodialysis
Hematocrit \< 30%
Severe chronic lung disease that limits activity or requires oxygen
Pregnancy
Implantable cardioverter defibrillator battery longevity \< 1 year
Vulnerable populations such as prisoners and institutionalized individuals
  • Change in left ventricular ejection fraction by echocardiogramat baseline versus 2 weeks, 4 weeks, 6 weeks from start of intervention/sham and at 3 months and 12 months after completion of intervention vs. sham.

    The change in left ventricular ejection fraction from baseline as determined by echocardiography