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4-Aminopyridine for Skin Wound Healing

This study is looking into whether 4-aminopyridine (4-AP) can help wounds heal faster in healthy adults. Many people experience wounds, and researchers want to find better ways to speed up healing. You might be eligible if you are an otherwise healthy adult between 18 and 70 years old, without skin conditions affecting your armpit or upper inner arm. Participants will receive either 4-aminopyridine or a placebo (an inactive substance). The main goal is to see if skin integrity and wound closure are achieved after a skin punch biopsy (a small skin sample taken for study) within 6 weeks. The current status of this study is unclear, and it plans to enroll 150 participants.

Study design
This interventional study plans to enroll 150 participants. It compares 4-aminopyridine to a placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measures wound healing at 6 weeks after a skin punch biopsy.

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NCT06333171

4-aminopyridine for Skin Wound Healing

Recruiting
PHASE2Ages 18–70InterventionalTreatment
John Elfar
~150 participants
Updated 2025-09-03 on ClinicalTrials.gov
What's tested:4-AminopyridinePlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Return of skin integrity and wound closure after skin punch biopsy
Measured over 6 weeks

Conditions

Wounds
Wound of Skin
Wound Heal
Wounds and Injuries

Explore related trials

Wound

Where it's being run

1 sites across 1 states
Arizona1

Study leadership

  • John Elfar, MD · PRINCIPAL_INVESTIGATOR · University of Arizona

Who to contact

Andrea Horne
[email protected]
520-626-6456
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Otherwise healthy adult patients without skin conditions effecting the skin of the axilla or upper inner arm.
Cognitive ability to evaluate wound healing, report sensory and motor deficit during examination.
Eligible for standard of care plan for wound closure by secondary intention (normal healing without intervention).
Adults subject aged 18-70
Ability to give written informed consent.
Capable of safely coming in for follow up visits on all scheduled appointments.

Exclusion

History of multiple sclerosis, stroke or any other diagnosed neurological disorder
History of hypersensitivity to AMPYRA® or 4-aminopyridine
Current use of aminopyridine medications, including other compounded 4-AP
Suspected renal impairment based on the Choyke questionnaire.
History of difficult compliance with timely follow up
Patients outside the age range
Unable to provide informed consent.
Patients with a known history of a seizure disorder (4-AP overdose can, in selected cases, result in limited seizure activity).
Patients with a concomitant traumatic brain injury.
Patients unable to communicate.
Patients unwilling to complete the study requirements.
Patients currently taking organic cat-ion transporter 2 (OCT2) inhibitors, e.g. Cimetidine.
Pregnancy, breastfeeding or incarcerated individuals.
Non-English speaking
Patients unable or unwilling to take calibrated (with gauge) photographs of their wounds

What this trial measures

  • Return of skin integrity and wound closure after skin punch biopsy6 weeks

    Axillary skin punch biopsies will be performed on healthy volunteers. Wound healing will be measured using visual assessment.