Oral Contraceptive Pill Pharmacogenomics Study

This study aims to understand how your unique DNA affects how your body processes the hormones in oral contraceptive pills (birth control pills). Specifically, researchers are looking at how a common birth control pill, Desogestrel / Ethinyl Estradiol, is broken down in your body. They want to see if differences in your DNA can explain why these pills work differently for some people or cause different side effects. The study is open to women aged 18 to 45 who are in good general health. The main goal is to measure the levels of the hormones etonogestrel and ethinyl estradiol in your blood after taking the pill.

Study design
This is an interventional study planning to enroll 700 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Hormone levels will be measured on Cycle 1, Day 22 (each cycle is 28 days).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06334315

Oral Contraceptive Pill (OCP) Pharmacogenomics

Recruiting
PHASE4Ages 18–45InterventionalTreatment
Yale University
~700 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Desogestrel / Ethinyl Estradiol Pill

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Serum etonogestrel concentration
Measured over Measured as a trough concentration on Cycle 1, Day 22 (each cycle is 28 days)
+1 more outcome measured
Contraception
Pharmacogenomic Drug Interaction
2 sites across 2 states
Colorado1
Connecticut1
  • Aaron M Lazorwitz, MD, PhD · PRINCIPAL_INVESTIGATOR · Yale University

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  • Serum etonogestrel concentrationMeasured as a trough concentration on Cycle 1, Day 22 (each cycle is 28 days)

    Pharmacokinetic measurement for progestin

  • Serum ethinyl estradiol concentrationMeasured as a trough concentration on Cycle 1, Day 22 (each cycle is 28 days)

    Pharmacokinetic measurement for estrogen