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Physiology of Unloading VA ECMO Trial for Cardiogenic Shock

This study is looking at how to best treat patients with cardiogenic shock (CS), a serious condition where your heart can't pump enough blood. Specifically, it's comparing two approaches for patients already on veno-arterial extracorporeal membrane oxygenation (VA ECMO), a machine that helps your heart and lungs. Some participants will receive an intra-aortic balloon pump (IABP) in addition to VA ECMO, while others will not. The researchers want to see if adding the IABP helps reduce fluid buildup in the lungs, improves heart function, and helps the heart recover. You may be able to join if you are an adult (18 or older) with acute cardiogenic shock and are failing standard medical treatments.

Study design
This study plans to enroll 104 participants and will randomly assign them to receive or not receive an intra-aortic balloon pump (IABP) while on VA ECMO.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be monitored at the start of ECMO, on day 5 of ECMO, when ECMO is removed (up to 3 months), and on the day you leave the ICU (up to 6 months).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06336655

Physiology of Unloading VA ECMO Trial

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of Utah
~104 participants
Updated 2026-04-30 on ClinicalTrials.gov
What's tested:IABP

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in pulmonary capillary wedge pressure
Measured over ECMO start, ECMO day 5, ECMO decannulation up to 3 months, day of ICU discharge up to 6 months

Conditions

Cardiogenic Shock

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NCT06336655

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Utah

    Salt Lake City, Utahstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Joseph E. Tonna, MD, FAAEM
[email protected]
801.587.9373
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Adult patients (age 18 years or older)
Diagnosis of acute cardiogenic shock (CS)
Patients failing medical therapy, defined as 1 or more of the following:

Exclusion

Metastatic or stage 4 cancer
Atrial septostomy
Planned LV unloading on ECMO
Anticipated death \<72 hours
Existing durable left ventricular assist device (dLVAD)
Unwillingness to randomize
Patients who are pregnant

What this trial measures

  • Change in pulmonary capillary wedge pressureECMO start, ECMO day 5, ECMO decannulation up to 3 months, day of ICU discharge up to 6 months

    Change in pulmonary capillary wedge pressure (PCWP) from ECMO start to ECMO day 5 (Day 5 - Baseline) with and without LV unloading