Remotely Observed Methadone Evaluation II for Opioid Use Disorder

This study is looking at a new way to help people with Opioid Use Disorder (OUD) who are taking methadone. Currently, methadone often requires daily visits to a clinic. This study is testing a special app called Sonara, which uses video recording and a tamper-evident seal to allow you to take your methadone at home more often. Researchers want to see if using Sonara helps people stay in treatment longer and reduces opioid use, compared to the usual way of getting methadone. You might be able to join if you are 18-64 years old, willing to be in a randomized study, and can complete interviews. You cannot join if you are pregnant, involved in the criminal justice system, have serious mental health problems, or are being treated with bupuprenorphine. The study aims to enroll 100 participants, but its current status is unclear.

Study design
This is an interventional study comparing the Sonara app to usual methadone take-home practices. It is a randomized trial, meaning participants will be assigned by chance to one of the two groups. The study plans to enroll 100 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will follow participants for 24 weeks to measure how long they stay in treatment and how many take-home doses they receive.

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NCT06338280

Remotely Observed Methadone Evaluation II

Recruiting
PHASE2Ages 18–64InterventionalSupportive care
Sonara Health
~100 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:Sonara

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Retention
Measured over 24 weeks
+1 more outcome measured
Opioid Use Disorder
1 sites across 1 states
Illinois1

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Eligibility criteria

Inclusion

Willing to participate in a randomized trial
Able to complete study instruments and interviews

Exclusion

Less than 18 years of age
Pregnant or planning to be pregnant
Currently involved in the criminal justice system
Serious mental health problems
Treated with buprenorphine
  • Retention24 weeks

    Length of time the patient remains in treatment after study enrollment

  • Take homes received over time24 weeks

    The number of take home doses of methadone received at 4-, 12-, and 24-weeks following randomization