Understanding Maternal Health After Preeclampsia

This observational study aims to understand why some women develop health problems after experiencing preeclampsia (high blood pressure during pregnancy) or gestational hypertension (high blood pressure that starts during pregnancy). Researchers will collect information and samples from pregnant women who are at different risk levels for these conditions. The goal is to find ways to identify women who might be at risk for heart and blood vessel problems after pregnancy and offer them preventative care. You can join if you are a pregnant woman between 18 and 50 years old, 10-24 weeks pregnant with a single baby, and plan to deliver at UCSD or VUMC. The study will look at preeclampsia, gestational hypertension, and postpartum hypertension (high blood pressure after delivery) during pregnancy and up to 13 months after birth.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. They plan to include 1100 pregnant women.
What's involved
You would participate from your second trimester until one year after delivery. This involves short in-person visits (about 30 minutes) for biosamples, surveys, and cardiovascular assessments, plus researchers will review your medical records.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed from the second trimester of pregnancy until 13 months postpartum.

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NCT06340152

Multi-Omics for Maternal Health After Preeclampsia

Recruiting
Not specifiedAges 18–50Observational
University of California, San Diego
~1,100 participants
Updated 2025-04-06 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Preeclampsia
Measured over 2nd trimester - 13 months postpartum
+2 more outcomes measured
Pre-Eclampsia
Pregnancy Induced Hypertension
1 sites across 1 states
California1
  • Louise Laurent, MD, PhD · PRINCIPAL_INVESTIGATOR · UCSD
  • Marni Jacobs, PhD · PRINCIPAL_INVESTIGATOR · UCSD

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Eligibility criteria

Inclusion

Pregnant women 18 years of age to 50 years of age
10-24 weeks gestation at time of enrollment
Singleton pregnancy
Planning to deliver at a study site (UCSD or VUMC)

Exclusion

Inability to give informed consent
Intrauterine fetal demise
Fetal genetic or structural anomaly
Institutionalization for psychiatric disorder, mental deficiency or incarcerated
Active or history of malignancy requiring major surgery or systemic chemotherapy
Multi-fetal gestation or a twin demise at any gestational age
Known maternal or fetal chromosomal anomalies
Patients who plan to keep their placenta after delivery
  • Preeclampsia2nd trimester - 13 months postpartum
  • Gestational hypertension2nd trimester - Delivery
  • Postpartum hypertensionDelivery - 13 months postpartum