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Study on Exercise and Cognitive Training to Prevent Alzheimer's

This study, called the Exergames Telerehabilitation Study, is looking at whether combining aerobic exercise (HbAEx) with cognitive training (HbExergame) can help prevent Alzheimer's disease in older adults who are at risk. You might be eligible if you are 65 or older, speak English, and have noticed some memory or cognitive difficulties, but your cognitive test scores (Montreal Cognitive Assessment or MoCA) are still good (26 or higher). The study will measure changes in your overall thinking abilities (fluid cognition) after 12 weeks to see if the interventions are successful. The current status of this study is unclear, and it plans to enroll 104 participants.

Study design
This is an interventional study planning to enroll 104 participants. It is not specified if it is randomized, blinded, or its phase.
What's involved
Participants will have a 1-week (3 session) onboarding period where equipment will be delivered to their home, and they will be supervised for the first three sessions. The study measures fluid cognition at 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 12 weeks, which suggests a follow-up period of at least that long.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06340659

Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)

Active, Not Recruiting
NAAges 65–99InterventionalPrevention
University of Minnesota
~104 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:HbAExHbExergame

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
fluid cognition (global cognition)
Measured over 12 weeks

Conditions

At Risk for AD-dementia, With Subjective Cognitive Decline

Explore related trials

Subjective Cognitive Decline

Where it's being run

1 sites across 1 states
Minnesota1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Cognitive complaint (defined as answering yes to the questions's "Do you perceive memory or cognitve difficulties?" and "In the last two years, has your cognition or memory declined?";
Montreal Cognitive Assessement (MoCA) 26 or greater
Age 65 years and older;
English-speaking;
Without ACSM contraindication to exercise

Exclusion

Dementia or mild cognitive impairment diagnosis;
Neurological or major psychiatric disorder, alcohol/chemical dependency or recent medical condition (anethesia COVID-19 \["brain fog"\]) likely causing cognitive impairment;
Current enrollment in another intervention study

What this trial measures

  • fluid cognition (global cognition)12 weeks

    which refers to the overall cognitive ability and will be assessed with the NIH Toolbox Cognitive Battery (NIHTB-CB) and its Fluid Composite Score (convergent validity \[r = 0.78\] and test-retest reliability \[r = 0.86)