COES: Curing Order Effects on Sealants

This study is looking at how long dental sealants last when placed in two different ways. One way uses a bonding agent (Ultradent Ultra Seal XT Plus) that is cured (hardened with light) before the sealant is applied. The other way uses the same bonding agent, but it is not cured before the sealant. The study aims to see which method leads to sealants lasting longer over two years. Children aged 5 to 14 who have healthy permanent molars without fillings or other problems can join. The study is currently unclear on its recruitment status and plans to enroll 217 participants.

Study design: This is a randomized study comparing two different methods of placing dental sealants in 217 children. One side of a child's mouth will be randomly chosen for one method, and the other side for the other method.
What's involved: You would have dental sealants placed on your permanent molars. You would then have follow-up visits at 6, 12, 18, and 24 months for evaluations and photos.
Compensation: Not stated in the trial record.
Follow-up: Participants will be followed for two years to check the longevity of the sealants.

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COES: Curing Order Effects on Sealants

Recruiting

PHASE1Ages 5–14InterventionalTreatment

University of Southern California

~217 participants

Updated 2026-07-02 on ClinicalTrials.gov

What's tested:Ultradent Ultra Seal XT Plus

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Sealant Longevity

Measured over 2 years

Conditions

Dental Sealant

Sealant Retention

Where it's being run

1 sites across 1 states

California1

Who to contact

Catherine Pham, DDS

[email protected]

2137400412

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

ASA I and ASA II children, aged 5 to 14 years who are patients of CDHC and USC with adequate eruption of permanent first or second molars for placement of sealants

These teeth will not have previous restorations, interproximal lesions, pathology, or occlusal lesions.

Behavior of the children should be within a Frankl 3 or 4 category, indicating a "positive" and "Definitely Positive" behavior rating, which would allow for safe and controlled execution of the proposed protocol

Patient must have contralateral molars in the same arch in which sealants can be placed. For example a child with #30 and #19 present will qualify for the study.

Exclusion

Any tooth with previous sealant placement

Children who are allergic or intolerant to sealant material

Children who cannot tolerate a dental suction isolation system, such as DryShield isolation

Children who do not complete a prophy cup polish.

Children who present with banded or bracketed molars

Patients or Parents who cannot fully understand an English or Spanish Consent/ Assent form.

Patients can withdraw voluntarily at any time.

Any tooth which has progression of caries beyond ICCMS Category 3 will be withdrawn from the study. These teeth will be treated with appropriate restorative dental treatment according to the standard of care.

Any qualifying tooth that subsequently requires a restoration due to trauma will be withdrawn from the study.

Any patient with an adverse reaction to treatment will be withdrawn. This event will be reported to the IRB.

What this trial measures

Sealant Longevity2 years
The primary outcome is measuring sealant longevity with intraoral photos and clinical exams. The outcome will be measured as retention (yes/no) and will be evaluated at 4 time points: 6 months, 12 months, 18 months, and 24 months as compared to initial baseline photos taken at treatment day. Patients/parents will be blinded to treatment status. The evaluation of intraoral photos will be performed by blinded practitioners.

Trialytics