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Comparing Laser Technologies for Kidney and Ureteral Stones

This study is comparing two ways to use a high-powered Holmium:YAG laser for treating kidney and ureteral stones (stones in the tube connecting the kidney to the bladder). Both methods use "dusting," where the laser breaks stones into tiny pieces that pass in your urine. One method uses "Dusting without Moses 2.0 Modulation" and the other uses "Dusting with Moses 2.0 Modulation." Researchers want to see if one method is better at reducing operating room time and increasing the "stone free rate" (meaning no stones are left) 6-8 weeks after the procedure. You may be able to join if you are 18-90 years old, need ureteroscopy and laser lithotripsy, and have kidney or ureteral stones between 8 and 20 mm. This study is currently recruiting 150 participants.

Study design
This is an interventional study where participants are randomly assigned to one of two treatment groups, like flipping a coin. Neither you nor your doctor will choose which treatment you receive.
What's involved
On the day of surgery, you will receive one of the assigned laser treatments. You will have follow-up appointments with a renal bladder ultrasound (RBUS) and Kidney Ureter Bladder Abdominal X-ray (KUB) 8 to 12 weeks after surgery.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for 8 to 12 weeks after surgery to check for stones and kidney swelling (hydronephrosis).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06346483

Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Moses On or Moses Off

Active, Not Recruiting
NAAges 18–90InterventionalTreatment
Northwestern University
~150 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:Dusting without Moses 2.0 ModulationDusting with Moses 2.0 ModulationMoses 2.0 Modulation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Operative time
Measured over Day of procedure
+1 more outcome measured

Conditions

Kidney Stone
Ureteral Stone

Explore related trials

NephrolithiasisUreterolithiasis

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Amy Krambeck, MD · PRINCIPAL_INVESTIGATOR · Northwestern University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Undergoing ureteroscopy and laser lithotripsy
Stone size ≥8 but \< 20 mm in the proximal ureter or kidney. Multiple stones ≤4 are allowed. Bilateral surgeries are allowed
Willing to sign informed consent

Exclusion

Staged surgery
Nephrocalcinosis
Participant is less than 18 years of age
Inability to provide informed consent
Members of vulnerable patient populations

What this trial measures

  • Operative timeDay of procedure

    Total amount of time (in minutes) taken to complete the procedure.

  • Stone Free Rate6-8 weeks post procedure

    This is measured by KUB and Renal bladder ultrasound that is post-operative standard of care. Stone free is defined as no stone fragments seen on KUB or RBUS. If there are hyperechoic fragments seen on RBUS but not KUB and the stone analysis was not uric acid, the patient will be considered stone free. The investigators will also calculate a clinically stone free rate (\< 4mm residual fragments allowed). The Stone Free Rate assessments by the investigators will highlight the rate, or ratio of patients who are stone free and patients who are not stone free after procedure.