Comparing Zinc-Amino Acid and Zinc Gluconate for Metabolic Effects

This study is looking at how two different forms of zinc supplements, zinc-amino acid (ZnAA) and zinc gluconate, affect your body's metabolism. Specifically, it's interested in how these supplements impact the 'Response of Fatty Acid Desaturation to Zinc Intake,' which is a process related to how your body uses fats. Researchers want to see if one form of zinc is better than the other at influencing this process. You might be able to join if you are a healthy man between 18 and 50 years old, with a body mass index (BMI) between 18 and 30. The study will measure changes in FADS1 activity, an indicator of this metabolic process, over several weeks. The current status of the study is unclear, and it plans to enroll 30 participants.

Study design
This interventional study plans to enroll 30 healthy men. It compares two different zinc supplements to see their effects.
What's involved
You would take a zinc supplement daily for 13 days, followed by a two-week break, and then take another zinc supplement for 13 days. You would also have four blood draws over approximately six weeks, each after an 8-hour fast.
Compensation
Not stated in the trial record.
Follow-up
Your FADS1 activity will be measured at four time points over approximately six weeks, with the last measurement at day 43.

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NCT06348056

A Comparison of the Metabolic Effects of Zinc-Amino Acid (ZnAA) Versus Zinc Gluconate

UNKNOWN
NAAges 18–50InterventionalBasic science
University of California, Berkeley
~30 participants
Updated 2024-04-08 on ClinicalTrials.gov
What's tested:30 mg Zn Amino Acid daily for 13 days30 mg Zn Gluconate daily for 13 days

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
FADS1 activity index
Measured over Day 1 (baseline 1), day 15 (endpoint 1), day 29 (baseline 2), day 43 (endpoint 2)
Response of Fatty Acid Desaturation to Zinc Intake
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Apparently healthy men (i.e., have no current health issues requiring medications or a specific diet)
18 to 50 years of age
Body mass index between 18 and 30 kg/m2
Willing to take zinc supplements provided by the study for a total of four weeks

Exclusion

History of heart disease, any inflammatory disorder including inflammatory bowel syndrome or arthritis, or any cancer treatment, or previously diagnosed with HIV
Smoking or alcohol abuse, use of illicit drugs
Any contraindication to venipuncture such as bleeding disorders or use of blood thinners
Those taking vitamins or supplements including minerals and omega oils, who cannot agree to stop taking the supplements two weeks prior to the study and for the duration of the study
  • FADS1 activity indexDay 1 (baseline 1), day 15 (endpoint 1), day 29 (baseline 2), day 43 (endpoint 2)

    The molar ratio (unitless) of arachidonic acid to dihomo-gamma-linolenic acid, i.e., fatty acid desaturase 1 (FADS1) product to precursor.