Study on THC, Eye Movement, and Thinking Skills
This study is looking at how different amounts of cannabis (with 0, 5, or 30 mg of THC) affect your eye movements and thinking skills. Researchers want to see if these effects are different for people who use cannabis often compared to those who use it rarely. They also want to find out if changes in eye movement can accurately show when someone is impaired by THC. You can join if you are a healthy adult between 18 and 60 years old. You must either use cannabis infrequently (at least once in the past year, with a negative THC urine test at the start) or frequently (more than 5 days a week for over a year, with a positive THC urine test at the start). The study aims to understand how THC and how often you use cannabis impact your eye movements and sustained attention (your ability to focus). The current status of this study is unclear.
- Study design
- This is a double-blind, placebo-controlled study with all participants trying different doses of THC. It plans to include 40 participants.
- What's involved
- You will inhale cannabis with different THC levels. Your eye movements and reaction times will be measured before and after taking cannabis, and again at 2 and 4 hours later.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your performance will be measured up to 4 hours after taking cannabis.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Dustin C Lee, PhD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Commission Errorspre-administration, post-administration, 2, 4 hours
The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Commission errors is measured by calculating the number of trials participants incorrectly push the spacebar in the presence of "X" stimulus.
- Omission Errorspre-administration, post-administration, 2, 4 hours
The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Omission errors is measured by calculating the number of trials participants fail to push the spacebar in the presence of a letter that is not an "X" stimulus.
- Reaction Timepre-administration, post-administration, 2, 4 hours
The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Reaction time is measured by calculating the duration between the presentation of a letter other than "X", and the correct response of a spacebar push.
- Reaction Time Standard Errorpre-administration, post-administration, 2, 4 hours
The Conners Continuous Performance Test (CPT) will be used to assess sustained attention. Reaction time standard error is measured by calculating the standard error of the mean of the reaction time.
- Visuomotor Indexpre-administration, post-administration, 2, 4 hours
The visuomotor index score is calculated by mathematically integrating five measures of oculomotor fixation performance and two measures of accuracy into a single score during fixation and accuracy tasks, respectively. Test of visual fixation to measure microsaccades, spontaneous nystagmus, and gaze-evoked nystagmus.