Cenobamate for Severe Seizures in the ICU
This study is looking at how the medication cenobamate works in people who are having frequent seizures or a prolonged seizure (status epilepticus) in the intensive care unit (ICU). Researchers want to see if cenobamate can reach certain levels in your body to help control these seizures. You might be able to join if you are between 18 and 70 years old, are having acute frequent seizures or status epilepticus, and are already undergoing EEG monitoring. The study will measure the amount of cenobamate in your body at 6 hours after the first dose and for up to 14 days. The current status of this study is unclear, and it plans to enroll 10 patients.
- Study design
- This is an interventional study involving 10 patients. It is a multi-center trial, meaning it will take place at several hospitals.
- What's involved
- You would receive cenobamate daily for up to 14 days, or until your seizures stop or a specific safety score is reached. Your cenobamate dose may be adjusted during this time.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your cenobamate levels will be monitored for up to 14 days after starting the medication.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cenobamate in the Intensive Care Unit
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jong Woo Lee, MD, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Target level6 hours after bolus
Percentage of patients reaching target level of 10±2 ug/mL after load.
- Maintenance levelUp to 14 days
Percentage of patients maintaining daily therapeutic level of 10±2 ug/mL