Cenobamate for Severe Seizures in the ICU

This study is looking at how the medication cenobamate works in people who are having frequent seizures or a prolonged seizure (status epilepticus) in the intensive care unit (ICU). Researchers want to see if cenobamate can reach certain levels in your body to help control these seizures. You might be able to join if you are between 18 and 70 years old, are having acute frequent seizures or status epilepticus, and are already undergoing EEG monitoring. The study will measure the amount of cenobamate in your body at 6 hours after the first dose and for up to 14 days. The current status of this study is unclear, and it plans to enroll 10 patients.

Study design
This is an interventional study involving 10 patients. It is a multi-center trial, meaning it will take place at several hospitals.
What's involved
You would receive cenobamate daily for up to 14 days, or until your seizures stop or a specific safety score is reached. Your cenobamate dose may be adjusted during this time.
Compensation
Not stated in the trial record.
Follow-up
Your cenobamate levels will be monitored for up to 14 days after starting the medication.

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NCT06352723

Cenobamate in the Intensive Care Unit

Not Yet Recruiting
EARLY_PHASE1Ages 18–70InterventionalTreatment
Brigham and Women's Hospital
~10 participants
Updated 2026-03-30 on ClinicalTrials.gov
What's tested:Cenobamate

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Target level
Measured over 6 hours after bolus
+1 more outcome measured
Epilepsy
Neurologic Disorder
1 sites across 1 states
Massachusetts1
  • Jong Woo Lee, MD, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

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Eligibility criteria

Inclusion

Age 18-70.
Undergoing EEG monitoring.
Acute frequent seizures (\>1/hour) or status epilepticus (\>5 min of consecutive seizures, or seizure burden \>20% within past 1 hour).
Adjunctive conventional antiseizure medication indicated.

Exclusion

History of medication-related rash.
On medication or device affecting enteral absorption (e.g., phenobarbital, pentobarbital).
Counterindication to cenobamate as described in the prescribing information.
  • Target level6 hours after bolus

    Percentage of patients reaching target level of 10±2 ug/mL after load.

  • Maintenance levelUp to 14 days

    Percentage of patients maintaining daily therapeutic level of 10±2 ug/mL