Understanding Obesity and Brain Activity with Protein Intake
This study is looking at how a family history of obesity might affect how your brain responds to protein and how much food you eat. Researchers want to see if there's a link between having a parent who had obesity and how well protein helps you feel full. You might be eligible if you are between 18 and 35 years old, have a BMI (Body Mass Index) between 20-40, and your weight has been stable for at least three months. You also can't have certain psychiatric or neurological conditions. Participants will consume either Ensure (a liquid meal with protein) or water before eating pizza. The main goals are to measure how much pizza is eaten and to look at brain activity in specific areas (medial and lateral prefrontal cortex) using a special brain imaging technique. The study's current status is unclear.
- Study design
- This is an interventional study planning to enroll 80 participants. It will compare how different pre-meal drinks (Ensure or water) affect food intake and brain activity.
- What's involved
- Participants will consume either Ensure or water before eating pizza. Brain activity will be measured at 20 minutes, and pizza consumption will be measured between 3-15 minutes.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints are measured at 3-15 minutes for pizza consumption and at 20 minutes for brain activity.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Grams of pizza consumed3-15 minutes
Ad libitum during the pizza eating episode
- Baseline medial prefrontal cortex oxygenated hemoglobin20 minutes
Micromoles per millimeter of oxygenated hemoglobin of the medial prefrontal cortex prior to pizza consumption
- Baseline lateral prefrontal cortex oxygenated hemoglobin20 minutes
Micromoles per millimeter of oxygenated hemoglobin of the lateral prefrontal cortex prior to pizza consumption
- medial prefrontal cortex Oxygenated hemoglobin concentration3-15 minutes
Micromoles per millimeter of oxygenated hemoglobin of the medial prefrontal cortex during pizza consumption phase
- lateral prefrontal cortex Oxygenated hemoglobin concentration3-15 minutes
Micromoles per millimeter of oxygenated hemoglobin of the lateral prefrontal cortex during pizza consumption phase