Adversity, Brain, and Opioid Use Study
This study is looking at how the brain processes and remembers information, especially in relation to past difficult experiences and Opioid Use Disorder (OUD). Researchers want to understand brain function and performance during learning and memory tasks. You might be eligible if you are between 18 and 55 years old, speak English fluently, and have normal vision and hearing. The study is comparing three groups: people with OUD who are taking buprenorphine, people without OUD who are taking buprenorphine, and healthy adults who are not taking buprenorphine. The main goals are to see differences in brain activity (Blood Oxygen Level Dependent or BOLD signal), brain volume, and brain connections in a specific area called the hippocampus. The current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 185 participants across three groups. It is not specified if the study is randomized or blinded.
- What's involved
- You would have two visits. On Day 1, you would complete computer tasks. On Day 2, you would have an MRI scan while completing various tasks.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary measurements are taken on Day 2 (MRI task visit).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Adversity, Brain and Opioid Use Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Elizabeth Duval · PRINCIPAL_INVESTIGATOR · University of Michigan
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Differences in Blood Oxygen Level Dependent (BOLD) signal in the hippocampusDay 2 (MRI task visit)
BOLD signal during functional magnetic resonance imaging (fMRI) will be used as a measure of hippocampus activation when remembering common objects and scenes. The study team will examine differences between participants with Opioid Use Disorder (OUD) and those without OUD.
- Differences in Hippocampal (Hpc) volumeDay 2 (MRI task visit)
T-1 weighted structural images for each participant will be used to compute the volume of the hippocampus in people with OUD compared to those without OUD.
- Differences in hippocampal circuit connectivityDay 2 (MRI task visit)
Functional connectivity, measured with BOLD signal will be used to examine functional connectivity between the hippocampus, amygdala, and prefrontal cortex. The study team will examine differences in connectivity between participants with OUD and those without OUD.
- Differences in performanceDay 1 (computer tasks visit)
Number of correct responses will be used to assess memory for common objects and scenes. Differences in memory will be examined in between participants with OUD and those without OUD.
- Differences in performanceDay 2 (MRI task visit)
Number of correct responses will be used to assess memory for common objects and scenes. Differences in memory will be examined in between participants with OUD and those without OUD.
- Differences in threat reactivity measured via skin conductance response (SCR)Day 1 (computer tasks visit)
Electrodermal activity collected with a bioamplifier will be used to quantify physiological reactivity to threat. Event related SCR will be measured as a baseline corrected response (peak minus baseline) to cues that predict threat compared to cues that do not predict threat. Differences in SCR between participants with OUD and participants without OUD will be examined.
- Differences in threat reactivity measured via skin conductance response (SCR)Day 2 (MRI task visit)
Electrodermal activity collected with a bioamplifier will be used to quantify physiological reactivity to threat. Event related SCR will be measured as a baseline corrected response (peak minus baseline) to cues that predicted threat on the previous day compared to cues that did not predict threat. Differences in SCR between participants with OUD and participants without OUD will be examined.