This study is looking at how the retina (the light-sensitive tissue at the back of your eye) might help us understand and treat Posttraumatic Stress Disorder (PTSD). Researchers believe there's a link between the brain and the retina, and that a test called an electroretinogram (ERG), which measures electrical activity in the retina, could be a useful tool. This pilot study will examine the ERG in U.S. military veterans with PTSD before and after they take a single dose of sertraline, a medication approved for PTSD. The goal is to see if ERG changes can tell us more about how well treatments like sertraline might work for PTSD. The study aims to enroll 50 participants.

Study design

This is an interventional pilot study with a planned enrollment of 50 participants. It involves taking an initial ERG, then taking a single dose of sertraline, and having a repeat ERG the next day.

What's involved

You would have an assessment including a history of traumatic events, mental health symptoms, ERG, vital signs, blood draw, and saliva sampling. You would then take a single dose of sertraline (50mg) and have a repeat ERG the following day. Some participants may also have a follow-up ERG up to one year later.

Compensation

Not stated in the trial record.

Follow-up

For a subset of participants, ERGs will be performed at a follow-up visit up to 1 year following baseline.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.