PICNIC Study: Antibiotic Courses for Children with Pneumonia

This study, called the PICNIC Study, is looking at a new way to decide how long children with complex medical needs should take antibiotics for pneumonia. Instead of using a set number of days, doctors will decide based on how stable your child's health is. The study wants to see if this approach can safely reduce how much antibiotic medicine children receive. You can join if your child is between 2 and 25 years old, has complex medical needs, is admitted to Boston Children's Hospital with pneumonia, and has started antibiotics. The study will measure how many eligible patients agree to participate, how often respiratory symptoms continue or get worse, and how often children need to go back to the emergency room or hospital within one week after stopping antibiotics. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 50 participants. It will compare basing antibiotic duration on clinical stability versus using predetermined total days of antibiotics.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for emergency department revisits or hospital readmission within 1 week of antibiotic discontinuation.

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NCT06364514

PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

Recruiting
NAAges 2–25InterventionalTreatment
Boston Children's Hospital
~50 participants
Updated 2025-11-12 on ClinicalTrials.gov
What's tested:Clinical Stability Assessment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of eligible patients who consent to participate in the intervention
Measured over 48 hours
+1 more outcome measured
Pneumonia
1 sites across 1 states
Massachusetts1

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Eligibility criteria

Inclusion

Admitted to the Complex Care Service at Boston Children's Hospital with a provider diagnosis of pneumonia
Started on antibiotics by the provider team
Ages 2-25 years old

Exclusion

Patients initially admitted to the intermediate care unit or ICU due to increased respiratory support needs
  • Proportion of eligible patients who consent to participate in the intervention48 hours

    Caregiver and medical provider acceptability

  • Rate of persistent and worsening respiratory symptoms measured by patient's clinical status; the rate of emergency department revisit or hospital readmission within 1 week of antibiotic discontinuation1 week

    Patient Safety Outcomes