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Nebulized Ketamine vs. Fentanyl for Acute Pain in the ED

This study is comparing two ways to give pain medication through a nebulizer (a device that turns liquid medicine into a mist you can breathe in) for adults with sudden, severe pain in the emergency department. Researchers are testing nebulized ketamine and nebulized fentanyl to see which one is better at reducing pain after 30 minutes. You might be able to join if you are 18 or older, have acute pain with a score of 5 or more, and can understand and communicate clearly. The study is currently unclear on its recruitment status and plans to enroll 150 participants.

Study design
This is a prospective, randomized, double-blind study comparing nebulized ketamine to nebulized fentanyl. About 150 participants will be randomly assigned to receive one of the two medications, and neither you nor your doctors will know which one you are receiving.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain will be measured at 30 minutes after receiving the medication.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06364540

Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED

Recruiting
PHASE4Ages 18+InterventionalTreatment
Antonios Likourezos
~150 participants
Updated 2025-06-04 on ClinicalTrials.gov
What's tested:KetamineFentanyl

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reduction of pain scores on the numeric rating pain scale (NRS)
Measured over 30 minutes

Conditions

Pain, Acute

Explore related trials

Acute Pain

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Sergey Motov, MD · PRINCIPAL_INVESTIGATOR · Maimonides Medical Center

Who to contact

Antonios Likourezos, MA, MPH
[email protected]
718-283-6896
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

age 18+ years
acute painful condition
pain score of 5 or more on a standard 11 point numeric rating scale (NRD)
patient needs to be awake, alert, and oriented as to person, place, and time
demonstrated understanding of the informed consent process and content
patient needs to demonstrate the ability to verbalize the nature of any adverse effects (AE)
patient needs to experience as well as express their pain severity by using the NRS

Exclusion

patient with a painful condition warranting emergent/urgent intervention in the ED
patients with altered mental status
allergy to ketamine or fentanyl
pregnant or breastfeeding
weight greater than 100 kg
patients presenting with head injury
unstable vital signs (systolic blood pressure \<90 mmHg or \>180 mmHg, pulse rate \<50 beats/min or \>150 beats/min, and respiration rate \<10 breaths/min or \>30 breaths/min)
inability to provide consent
current medical history of alcohol or drug abuse
administration of opioids or opioid antagonist/agonist within 4-6 hours prior to arrival and NSAIDs 6 hours prior to arrival to the t

What this trial measures

  • Reduction of pain scores on the numeric rating pain scale (NRS)30 minutes

    comparative reduction of pain scores on the numeric rating pain scale (NRS) between recipients of KetaBAN and FentaBAN