This observational study is looking at how a specific brain marker, Histone Deacetylase 6 (HDAC6), is different in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or both, compared to healthy individuals. Researchers will use special brain scans called PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) with a substance called [18F]Bavarostat to measure HDAC6 levels. The study aims to enroll 150 participants aged 18 to 70. By understanding these differences, the study hopes to guide the development of new treatments for these conditions. The study is currently unclear on its recruitment status.

Study design

This is an observational study planning to enroll 150 participants. It will compare HDAC6 levels in different groups of people.

What's involved

You would undergo MRI and PET brain imaging procedures, which involve up to two injections of [18F]Bavarostat, and complete behavioral and cognitive tasks.

Compensation

Not stated in the trial record.

Follow-up

HDAC6 expression will be measured at Baseline.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.