Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography

{ "ATHERO-RT: Real-Time Atherosclerosis Activity After Thoracic Radiotherapy", "This study is looking at how radiation therapy to the chest might affect your heart's arteries. Researchers will use a special scan called 18-F-NaF Cardiac PET/MRI (Positron Emission Tomography/Magnetic Resonance Imaging) to see changes in your arteries before and after radiation. They are also using a CT Angiogram (a special X-ray to look at blood vessels) at the start. This study is for people aged 18 or older who have cancer that has spread a little (oligometastatic disease) and are having radiation therapy to their chest, where the heart will be in the treatment area. The main goal is to see if these imaging methods can successfully detect changes in atherosclerosis (hardening of the arteries) after radiation. This is a small pilot study with 10 participants, and its current status is unclear.", "design": "This is a small, single-arm study, meaning all participants receive the same interventions. It plans to enroll 10 participants.", "commitments": "You would receive an 18-F-NaF Cardiac PET/MRI and a CT Angiogram at the beginning of the study. You would have another 18-F-NaF Cardiac PET/MRI 6 months after your radiation therapy is finished.", "compensation": "Not stated in the trial record.", "follow_up": "You will be followed for 6 months after completing your radiation therapy to assess the feasibility of the imaging.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06373497

Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography

Recruiting
EARLY_PHASE1Ages 18+InterventionalTreatment
Katelyn Atkins
~10 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:18-F-NaF Cardiac PET/MRI andCT Angiogram

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of using F-NaF PET/MRI imaging
Measured over 6 Months
Oligometastatic Disease

NCT06373497

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Cedars Sinai Medical Center

    Los Angeles, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Katelyn Atkins, MD, PhD · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center

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Eligibility criteria

Inclusion

Age ≥ 18 years.
Have clinical stage II-III or oligo-metastatic stage IV malignancy (any histology) planned to be treated with thoracic radiotherapy (≥30 Gy) where the heart is in the treatment field.
Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-2.
Planning to receive standard of care radiotherapy treatment.
Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
Ability to read, write, and understand English

Exclusion

Estimated glomerular filtration rate (eGFR) \<45 mL/min/m2 or serum creatinine ≥1.5 mg/dL.
Patients with a known or previous allergy to iodinated contrast, gadolinium contrast, and/or 18F-NaF tracer.
Inability to receive PET tracer.
Inability to receive MRI, requiring sedation for MRI, or prohibitive implant and/or device, including ferromagnetic implants and ferromagnetic foreign bodies.
Subjects with claustrophobia, problems being in enclosed spaces, or inability to lie supine.
Subjects that are pregnant or breastfeeding.
Subjects unable to comply with visit instructions, including inability to lie still, hold breathe, or follow procedure instructions.
Allergy to animal dander or animal-instigated asthma.
Any other condition which, in the opinion of the investigator, may make the patient a poor candidate for participation in a clinical trial
  • Feasibility of using F-NaF PET/MRI imaging6 Months

    To determine the feasibility of using 18F-NaF PET/MRI imaging for detection of real-time atherosclerosis activity in patients at high risk of RT-associated cardiac dysfunction.