Switch or Quit R01 Study for Smoking Cessation

This study is looking at whether e-cigarettes can help people quit smoking, compared to traditional methods like nicotine replacement therapy (NRT) or varenicline (Chantix). You might be able to join if you are 21 or older, have tried to quit smoking before using FDA-approved medications, and are interested in reducing harm from tobacco or quitting. Participants will be randomly assigned to one of two groups: one receiving e-cigarettes or one receiving FDA-approved medication (NRT or varenicline). The main goal is to see how many people successfully quit smoking for at least 7 days at 11 weeks. The study plans to enroll 225 people, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific intervention. You will be randomly assigned to one of two groups: e-cigarette or medication, with a planned enrollment of 225 participants.
What's involved
Participation will last 6 months. This includes weekly phone calls for the first 7 weeks, an 11-week phone call, and a 6-month follow-up visit.
Compensation
Not stated in the trial record.
Follow-up
Participants will have a 6-month follow-up visit after the initial 11-week assessment.

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NCT06373679

Switch or Quit R01

Recruiting
NAAges 21+InterventionalPrevention
Medical University of South Carolina
~225 participants
Updated 2026-07-13 on ClinicalTrials.gov
What's tested:Switching to E-CigaretteSwitching using Medication

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Biochemically-confirmed 7-day point prevalence abstinence from cigarettes on timeline followback
Measured over 11 Weeks
Cigarette Smoking
Smoking Behaviors
1 sites across 1 states
South Carolina1

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Eligibility criteria

Inclusion

Adults 21+ who previously had a quit attempt using FDA-approved pharmacotherapy.
Interest in reducing harms from tobacco use or quitting smoking

Exclusion

Pregnant, breastfeeding, or trying to become pregnant.
Household member currently enrolled in the study
Planning to move out of the area within the next 7 months
  • Biochemically-confirmed 7-day point prevalence abstinence from cigarettes on timeline followback11 Weeks

    Self-reported zero cigarettes in the past 7 days on timeline followback at Week 11 + expired carbon monoxide \< 6 ppm