Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production
This study is looking at how a probiotic called Herbiotics Oral + Ent Probiotic (containing Lactobacillus species) affects the body's ability to turn dietary nitrate into plasma nitrite. Nitric oxide (NO) is important for healthy blood flow, and your body can make it from nitrate found in foods like leafy greens. This process involves bacteria in your mouth. Researchers want to see if this probiotic can improve how your body converts nitrate to nitrite, which could help with conditions like high blood pressure (Hypertension), heart disease (Cardiovascular Diseases), and diabetes. They are looking for healthy adult volunteers between 18 and 70 years old. The main goal is to measure how much dietary nitrate is converted to plasma nitrite over two visits, eight days apart.
- Study design
- This is an interventional study with an unclear status, planning to enroll 20 participants.
- What's involved
- You would have two visits, 8 days apart. The study excludes individuals who have had more than 2 blood draws in one week or have a history of difficult blood draws.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, dietary nitrate conversion to plasma nitrite, is measured at two visits 8 days apart.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )
At a glance
Conditions
NCT06375694
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Wake Forest University
Winston-Salem, North Carolinastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Dietary Nitrate Conversion to Plasma NitriteThe two visits will be 8 days apart.
The main outcome is the plasma nitrite level 2.5 after consuming Beet Juice minus the plasma nitrite level prior to drinking beet juice. Blood will be collected prior to drinking one Beet it Sport shot and 2.5 hours after drinking the shot. Plasma nitrite will be measured from these blood draws. This outcome will be measured at two visits: baseline and followup (day 8) and the increase in plasma nitrite at the two visits will be compared. Between the two visits the participants will consume the Probiotic or Placebo for 7 days.