Genetic Testing for Specific Conditions

This study is looking at new ways to help people with certain health conditions get genetic testing. The conditions include genetic predisposition (an increased chance of developing a disease due to your genes), paraganglioma (a rare tumor), pheochromocytoma (a tumor of the adrenal gland), ALS (Lou Gehrig's disease), and Parkinson's disease. Researchers are testing if a "behavioral nudge" – a gentle reminder or suggestion – given to doctors or patients can increase the number of people who get genetic testing. The goal is to see if these nudges can make it easier for people to get genetic testing when the results could help guide their medical care. The study aims to enroll 1000 participants.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It is a pragmatic randomized clinical trial, which means participants will be randomly assigned to different groups to compare the effectiveness of various nudges.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, the rate of genetic testing, will be measured at 3 years.

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NCT06377033

Using the EHR to Advance Genomic Medicine Across a Diverse Health System

Recruiting
NAAges 18+InterventionalHealth services
University of Pennsylvania
~1,000 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Behavioral nudge

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of Genetic Testing
Measured over 3 years
Genetic Predisposition
Paraganglioma
Pheochromocytoma
ALS
Parkinson Disease
Polyneuropathies
Frontotemporal Dementia
Alzheimer Disease
Cardiomyopathy Non-ischemic
Thoracic Aortic Aneurysm
1 sites across 1 states
Pennsylvania1
  • Katherine L Nathanson, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylva
  • Robert Schnoll, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylva

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Eligibility criteria

Inclusion

18 years of age or older
diagnosed with one of the study conditions

Exclusion

Under 18 years of age
not diagnosed with one of the study conditions
  • Rate of Genetic Testing3 years

    The number of patients seen by the total number of genetic tests conducted