Glycyrrhizin for Prostate Cancer

This study is testing Glycyrrhizin (GLY) in men with prostate cancer who are planning to have surgery. You would either receive 75 mg of Glycyrrhizin daily, 150 mg of Glycyrrhizin daily, or no Glycyrrhizin, for about 5 weeks before your surgery. Researchers want to see if Glycyrrhizin can reduce prostate-specific antigen (PSA) levels, which is a marker for prostate cancer, before surgery. To join, you must be at least 18 years old, have prostate cancer that hasn't been treated yet, and be scheduled for a radical prostatectomy (surgery to remove the prostate). This study is looking for 60 participants, but its current recruitment status is unclear.

Study design
This is a pilot, randomized study where participants are assigned by chance to one of three groups. It is an interventional study, meaning participants will receive a specific treatment or observation.
What's involved
You would take Glycyrrhizin daily for about 5 weeks before your prostatectomy surgery. Your PSA levels will be checked after this treatment period.
Compensation
Not stated in the trial record.
Follow-up
The main goal is to check changes in PSA levels after treatment and before surgery, which is measured at 2 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06378346

GU-01: Glycyrrhizin in Prostate Cancer

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of Illinois at Chicago
~60 participants
Updated 2026-02-23 on ClinicalTrials.gov
What's tested:ObservationGlycyrrhizin - 75 mgGlycyrrhizin - 150 mg

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To evaluate anti-tumor activity of GLY by assessing changes in prostate-specific antigen (PSA) after GLY treatment administration and prior to radical prostatectomy
Measured over 2 months
Prostate Cancer
1 sites across 1 states
Illinois1
  • Natalie Reizine · PRINCIPAL_INVESTIGATOR · University of Illinois at Chicago

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  • To evaluate anti-tumor activity of GLY by assessing changes in prostate-specific antigen (PSA) after GLY treatment administration and prior to radical prostatectomy2 months

    Changes in prostate specific antigen (PSA) in patients with prostate cancer will be assessed before and after administration of GLY