Cottonseed Oil and Heart Health Study
This study is looking at how different oils in your diet affect your heart health, specifically your cholesterol levels. Researchers want to see if cottonseed oil (CSO) can improve cholesterol and other fat levels in your blood. You might be able to join if you are between 25 and 75 years old and have an increased risk for heart disease, such as high cholesterol or being overweight/obese. Participants will receive a breakfast shake for 28 days containing either cottonseed oil, a matched polyunsaturated fatty acid (PUFA) diet, or a control oil mixture. The study will measure changes in your cholesterol and other fat levels in your blood before and after the 28 days. The study aims to enroll 90 people.
- Study design
- This is a double-blinded, randomized control trial. It involves three different diet interventions and plans to enroll 90 participants.
- What's involved
- You would receive a breakfast shake daily for 28 days. Blood tests will be done at the beginning and after 4 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your blood levels will be measured at baseline and again after 4 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cottonseed Oil Versus Matched PUFA Effects
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jamie Cooper, PhD · PRINCIPAL_INVESTIGATOR · University of Georgia
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Change in fasting serum lipoprotein and cholesterol concentrationsbaseline, 4 weeks
The concentration of fasting serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein B (mg/dL)
- Change in fasting and postprandial plasma triglyceride concentrationsbaseline, 4 weeks
The concentration of plasma triglycerides before and after the high saturated fat meal challenge at both pre-and post-intervention visits (mg/dL)
- Change in fasting and postprandial plasma non-esterified fatty acid (NEFA) concentrationsbaseline, 4 weeks
The concentration of plasma NEFAs before and after the high saturated fat meal challenge at both pre- and post- intervention visits (mEq/L)
- Change in fasting and postprandial plasma appetite control hormones concentrationsbaseline, 4 weeks
The concentration of plasma appetite control hormones before and after the high saturated fat meal challenge at both pre- and post-intervention visits. Appetite control hormones include cholecystokinin (CCK), Peptide YY (PYY), Ghrelin (pg/mL)
- Change in fasting and postprandial subjective feelings related to appetitebaseline, 4 weeks
Visual analog scale ratings of feelings related to appetite before and after the high saturated fat meal challenge, and for the remainder of the day, at both pre- and post- intervention visits. Subjective feelings of hunger, fullness, desire to eat, prospective consumption and a composite appetite score are measured by visual analog scales (mm).
- Change in fasting and postprandial plasma Malondialdehyde (MDA)baseline, 4 weeks
The concentration of MDA before and after the high saturated fat meal challenge at both pre- and post- intervention visits (nmol/mL).
- Change in fasting and postprandial plasma total antioxidant capacitybaseline, 4 weeks
Total antioxidant capacity before and after the high saturated fat meal challenge at both pre- and post- intervention visits (U/mL).
- Change in fasting inflammatory cytokine concentrationsbaseline, 4 weeks
The concentration of interleukin-1 beta, C reactive protein, tumor-necrosis factor-alpha, and interleukin-6 at fasting at both pre-and post-intervention visits (pg/mL).
- Change in fasting plasma markers of coagulation potentialbaseline, 4 weeks
The concentration of plasminogen activator inhibitor-1, and tissue factor at fasting for both pre- and post- intervention visits (pg/mL)
- Change in fasting and postprandial plasma angiopoietin-like (ANGPTL) proteinsbaseline, 4 weeks
The concentration of ANGPTL 3, ANGPTL 4 and ANGPTL 8 before and after the high saturated fat meal challenge at both pre- and post- intervention visits (ng/mL)
- Desaturation indexbaseline, 4 weeks
Measurement of fatty acid concentrations for fasting and post-prandial plasma (ratio of unsaturated to saturated fatty acids)