This study is comparing two ways to give an antibiotic called vancomycin during total ankle replacement surgery. One group of patients will receive vancomycin through a standard IV (into a vein). The other group will receive vancomycin directly into the bone in the ankle (intraosseous injection). Researchers want to see if both methods deliver similar amounts of vancomycin to the bone, soft tissue, and throughout the body. They also want to compare infection rates 30 and 90 days after surgery between the two groups. You may be able to join if you are at least 18 years old and are having total ankle replacement surgery. The study is currently recruiting 40 participants.

Study design

This is an interventional study comparing two different ways to give antibiotics during surgery, involving 40 participants.

What's involved

You would receive vancomycin either intravenously or through an intraosseous injection during your total ankle replacement surgery. Tissue and blood samples will be taken during and immediately after the procedure.

Compensation

Not stated in the trial record.

Follow-up

Your post-operative complication rates (infection) will be compared at 30 and 90 days after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.