Raman Spectroscopy for Skin Cancer

This observational study is looking at whether a technology called Raman Spectroscopy can help doctors understand the size of skin cancer tumors. It uses a small, pen-sized handheld probe that gently touches your skin to take measurements with laser light. The goal is to see if this method can detect how far skin cancer (basal cell carcinoma or squamous cell carcinoma) has spread, even beyond what's visible. You could be eligible if you are 18 or older, have a confirmed diagnosis of basal cell or squamous cell skin cancer, and are planning to receive brachytherapy (a type of radiation therapy) for your skin cancer at the study site. The study aims to determine if Raman Spectroscopy can show differences between cancerous and non-cancerous skin.

Study design
This is an observational study planning to enroll 20 participants. It is not specified if it is randomized or blinded.
What's involved
You would have measurements taken with a handheld Raman Spectroscopy probe that lightly touches your skin. The record does not specify the number of visits or other procedures.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of the study will be measured at 1 year.

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NCT06384924

Raman Spectroscopy and Skin Cancer

Recruiting
Not specifiedAges 18+Observational
Tiezhi Zhang
~20 participants
Updated 2026-05-07 on ClinicalTrials.gov
What's tested:Raman Spectroscopy handheld probe (EmVision, FL, USA)Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of Raman Spectroscopy to observe differences in Raman spectra between visible lesion, skin surrounding lesion and contralateral normal skin.
Measured over 1 year
Skin Cancer
Basal Cell Carcinoma
Squamous Cell Carcinoma
1 sites across 1 states
New York1
  • Tiezhi Zhang · PRINCIPAL_INVESTIGATOR · Stony Brook Cancer Center

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Eligibility criteria

Inclusion

Histologically confirmed skin cancer (either basal cell carcinoma or squamous cell carcinoma)
Participants must plan to receive brachytherapy treatment for the skin cancer at the study site.
Ability to provide consent to the study.

Exclusion

Patient belongs to a vulnerable population (Minors (under 18 years old), Adults unable to consent, prisoners).
Lesions on the eyelid or in close proximity to the eye
Pregnant women, or women of childbearing age who refuse pregnancy testing.
Patient has pacemaker.
  • Feasibility of Raman Spectroscopy to observe differences in Raman spectra between visible lesion, skin surrounding lesion and contralateral normal skin.1 year

    Collect the Raman spectroscopy data starting from the center of visible lesion moving outward and also contralateral normal skin. Observe the different spectra peak wavelengths and intensities, which correspond to different chemical composition of the tissue. The Raman Spectra has units of wavelength Raman shift (1/centimeter) on the horizontal axis and arbitrary units of intensity on the vertical axis.