Back to search results
NCT06391294

Neuronal and Network Mechanisms of Electrocortical Stimulation

Enrolling by Invitation
NAAges 18–80InterventionalBasic science
Northwestern University
~65 participants
Updated 2025-09-09 on ClinicalTrials.gov
What's tested:Focal cortical cooling

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Critical node decoding performance
Measured over Up to 1 week during ECoG recording

Conditions

Epilepsy
Brain Tumor Adult

Explore related trials

Brain NeoplasmSeizure Disorder

Where it's being run

3 sites across 3 states
Illinois1
Iowa1
Maryland1

Study leadership

  • Marc Slutzky · PRINCIPAL_INVESTIGATOR · Northwestern University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Requiring awake, cortical mapping for brain tumor resection or implantation of intracranial electrodes for extraoperative monitoring for epilepsy
For extraoperative patients: Planned electrode coverage including at least parts of frontal and temporal or parietal lobes, preferably both anterior (inferior frontal gyrus) and posterior language areas (superior temporal gyrus) in the language dominant hemisphere
For intraoperative patients: Planned craniotomy including parts of both frontal and temporal anterior and posterior language areas in the language dominant hemisphere.

Exclusion

Significant language or speech impairment, including but not limited to aphasia, dysarthria, and apraxia of speech, consistently preventing patient from speaking words
Non English-speaking (because this is a study of language networks, and second language could be encoded differently)
Impaired cognitive function, as determined by neurological testing, such that the patient cannot follow test instructions or provide written informed consent
Tumor infiltrating, or within 1 cm of, multiple of the cortical or subcortical areas studied in this proposal (inferior frontal gyrus, precentral gyrus, superior temporal gyrus)
Ferromagnetic implants that are MRI incompatible or other contraindications to MRI
Pregnancy

What this trial measures

  • Critical node decoding performanceUp to 1 week during ECoG recording

    Accuracy at decoding critical nodes from network connectivity metrics using machine learning algorithms.