Integrated Treatment for Enhancing Growth in Recovery During Adolescence (InTEGRA) for Alcohol and Cannabis Use Disorder

This study is testing two different behavioral therapies for adolescents and young adults (ages 14-21) who have alcohol or cannabis use disorder. The therapies are called InTEGRA and MET/CBT. InTEGRA combines elements of 12-Step Facilitation with Motivational Enhancement Therapy/Cognitive Behavioral Therapy, while MET/CBT is Motivational Enhancement Therapy/Cognitive Behavioral Therapy alone. Researchers want to see if InTEGRA is effective in helping young people reduce their substance use. Success in this study means participants have more days without using substances and fewer problems related to substance use. The study is currently enrolling 294 participants in the Boston, MA, and Farmington, CT, areas.

Study design
This is a randomized controlled trial comparing two treatments, InTEGRA and MET/CBT, involving 294 participants. Participants are randomly assigned to one of the two treatment groups.
What's involved
You would undergo a phone screening, followed by a more detailed screening. If eligible, you would participate in a treatment program lasting about 3 months.
Compensation
Not stated in the trial record.
Follow-up
After treatment ends, you would have follow-up appointments every 3 months for one year to check on your progress.

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NCT06395467

Integrated Treatment for Enhancing Growth in Recovery During Adolescence

Recruiting
NAAges 14–21InterventionalTreatment
Massachusetts General Hospital
~294 participants
Updated 2026-03-06 on ClinicalTrials.gov
What's tested:InTEGRAMET/CBT

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent Days Abstinent (PDA)
Measured over During treatment and up to 12 months following enrollment
+1 more outcome measured
Alcohol Use Disorder
Cannabis Use Disorder
2 sites across 2 states
Connecticut1
Massachusetts1
  • John F Kelly, PhD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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  • Percent Days Abstinent (PDA)During treatment and up to 12 months following enrollment

    Percent Days Abstinent (PDA) from alcohol and other drugs (cannabis, opioids, etc.). Derived from Timeline Followback (TLFB) and Form-90 measures of substance use. Abstinence reports confirmed with Breathalyzer and Toxicology Screen data.

  • Substance use related consequencesDuring treatment and up to 12 months following enrollment

    Substance use related consequences as measured by the Short Inventory of Problems - Revised (SIP-2R), a 15-item measure with response options from 0 to 3 (minimum = 0 and maximum = 45); higher scores correspond with more consequences.