NCT06395506
THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation
Recruiting
NAAges 18–75InterventionalSupportive careThe University of Texas Medical Branch, GalvestonInvestigator-initiated
~60 participants
Updated 2025-12-24 on ClinicalTrials.gov
What's tested:Creatine
At a glance
Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in strength in breast cancer survivors
Measured over baseline and 12 weeks
+1 more outcome measured
Conditions
Where it's being run
1 sites across 1 statesTexas1
Study leadership
- Darpan Patel, PhD · PRINCIPAL_INVESTIGATOR · University of Texas
Who to contact
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Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Inclusion
Age 18-75 years of age
Diagnosis of breast cancer requiring chemotherapy
Recent (within 6 months) completion of chemotherapy
Willing to attend 3 virtual-based exercise sessions per week
Able to take oral medications
Participant is willing and able to provide consent to participating in the study
Serum creatinine ≤ 1.5 x ULN or Estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2 by Chronic Kidney Disease Epidemiology Collaboration equation.
Age 18-75 years of age
Have never been diagnosed with cancer
Willing to provide consent to participate in this study
Exclusion
Physical indications where performing exercise may be limited and/or contraindicated
Poorly controlled hypertension (blood pressure \> 160/95mmHg)
Current tobacco use (within 6 months)
Anabolic steroids use
Pitting edema greater than 2+
Currently undergoing chemotherapy treatment for cancer
History of moderate-severe heart disease (New York Heart Classification greater than grade II) or pulmonary disease (dyspnea on exertion upon climbing one flight of stairs or less; abnormal breath sounds on auscultation)
Pregnant or plan to become pregnant during the study
Recent (within one month) or anticipated treatment with corticosteroids (except for short term use during the time of chemotherapy), or other appetite stimulants
Serum creatinine \> 1.5 x ULN or Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m2 by Chronic Kidney Disease Epidemiology Collaboration equation
Currently taking creatine supplements
Lack of availability to a smartphone and/or internet
Physical indications where performing exercise may be limited and/or contraindicated
Poorly controlled hypertension (blood pressure \> 160/95mmHg)
Current tobacco use (within 6 months)
Anabolic steroids use
Pitting edema greater than 2+
History of cancer diagnosis
History of moderate-severe heart disease (New York Heart Classification greater than grade II) or pulmonary disease (dyspnea on exertion upon climbing one flight of stairs or less; abnormal breath sounds on auscultation)
Pregnant or currently taking prescribed medication to prepare for pregnancy (i.e.
Recent (within one month) treatment with corticosteroids
Recent (within one month) use of appetite stimulants or appetite suppressants
Serum creatinine \> 1.5 x ULN or Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m2 by Chronic Kidney Disease Epidemiology Collaboration equation
Diagnosed Bipolar Disorder or MDQ score indicative of bipolar disorder or Neurological disorders
Uncontrolled diabetes (A1c of 6.5% or higher)
Currently taking creatine supplements
Lack of availability to a smartphone and/or internet
What this trial measures
- Change in strength in breast cancer survivorsbaseline and 12 weeks
Determine the change in strength in breast cancer survivors by comparing pre and post measurements of strength measurement tools including 1RM/10RM/Biodex evaluations.
- Change in physical functional capacity in breast cancer survivorsbaseline and 12 weeks
Determine the change in strength in breast cancer survivors by comparing pre and post measurements of the six minute walk test.