Observational Study on Skin Changes with Aromatase Inhibitor Therapy

This observational study is looking at how aromatase inhibitor therapy, a common breast cancer treatment, affects skin quality and self-esteem in women who have had breast cancer. Researchers will use special imaging technology (Canfield Sciences VISIA-CA) and facial photographs to measure changes in your skin. They will also ask you to complete surveys about your self-esteem and how skin changes affect your daily life. The study aims to see if skincare advice from an aesthetician can improve skin quality and how you feel about yourself. This study is for postmenopausal women (ages 18 and older) with certain types of breast cancer (stages 0-III) that are estrogen receptor (ER) and/or progesterone receptor (PR) positive. The study plans to enroll 35 participants and will measure changes in skin quality for up to 6 months.

Study design
This is an observational study involving about 35 women. It does not involve a new treatment but rather observes the effects of existing aromatase inhibitor therapy.
What's involved
You would complete surveys, have your skin measured with a special device, have facial photographs taken, and attend consultations with an aesthetician.
Compensation
Not stated in the trial record.
Follow-up
Skin quality changes will be measured for up to 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06401889

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~35 participants
Updated 2026-05-19 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in skin quality
Measured over Up to 6 months
Anatomic Stage 0 Breast Cancer AJCC v8
Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage III Breast Cancer AJCC v8
Breast Adenocarcinoma
Estrogen Receptor-Positive Breast Carcinoma
Progesterone Receptor-Positive Breast Carcinoma
1 sites across 1 states
Florida1
  • Leila M. Tolaymat, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

\* Female ≥ 18 years
Postmenopausal women suitable to receive aromatase inhibitor as per physician's discretion
Histologically confirmed adenocarcinoma of the breast stage 0-III with estrogen receptor (ER) and/or progesterone receptor (PR) positive per American Society of Clinical Oncology (ASCO)/ College of American Pathologists (CAP) guideline and any human epidermal growth factor receptor 2 (HER2)
Patients must not have received any prior chemotherapy or endocrine therapy for their current breast cancer. Patients who received tamoxifen or raloxifene or another agent for prevention of breast cancer may be included
Patients willing to avoid any facial procedures including facials, neurotoxin injections, fillers, or lasers during study period
Willing and able to provide consent

Exclusion

\* Patients who have previously taken AIs
Patients using prescription tretinoin, neurotoxin injections, fillers, facial lasers, microneedling, or facials within 6 months of study consent
  • Changes in skin qualityUp to 6 months

    Changes in skin quality measured as incidence and severity of skin quality changes using VISIA-CA technology (skin analysis imaging system) and facial skin assessment photography.