Back to search results

Study of Wearable Robot for Acute Stroke Rehabilitation

This study is testing a new wearable robot designed to help people recover movement after a stroke. The robot provides different types of training, including motor relearning, passive stretching, game-based active movement, passive movement, and active movement training. This is for people who have had their first stroke, are between 30 and 85 years old, and have weakness or paralysis on one side of their body, especially in their ankle. The study aims to see if this early, intensive rehabilitation can improve ankle movement and overall recovery. We will measure improvements using the Fugl-Meyer Lower Extremity (FMLE) score at the beginning, end of a 3-week training period, and one month after training finishes. The study is currently recruiting participants.

Study design
This interventional study plans to enroll 68 participants. It is evaluating a new wearable rehabilitation robot for acute stroke survivors.
What's involved
Participants will undergo a 3-week training period. Their ankle movement will be measured at the start, end of training, and one month later.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one month after the treatment ends.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06404268

Facilitating Neuroplastic Changes of Acute Stroke Survivors

Recruiting
PHASE1Ages 30–85InterventionalTreatment
University of Maryland, Baltimore
~68 participants
Updated 2026-07-23 on ClinicalTrials.gov
What's tested:Motor relearning trainingPassive stretchingGamed-based active movement trainingPassive movementActive movement trainingAnkle torque and motion measurement

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Fugl-Meyer Lower Extremity (FMLE)
Measured over At the beginning and end of 3-week training, and 1 month after the treatment ends]

Conditions

Stroke

Explore related trials

ParaplegiaStroke

Where it's being run

3 sites across 2 states
Maryland2
Texas1

Study leadership

  • Li-Qun Zhang · PRINCIPAL_INVESTIGATOR · University of Maryland

Who to contact

Peiwen Fu, BS
[email protected]
410 706-8625
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Acute first time unilateral hemispheric stroke (hemorrhagic or ischemic stroke, 24 hours after admission to 1 month post-stroke at the start of the proposed treatment)
Hemiplegia or hemiparesis
0≤Manual Muscle Testing (MMT)\<=2
Age 30-85
Ankle impairments including stiff calf muscles and/or inadequate dorsiflexion

Exclusion

Medically not stable
Associated acute medical illness that interferes with ability to training and exercise
No impairment or very mild ankle impairment of ankle
Severe cardiovascular problems that interfere with ability to perform moderate movement exercises
Cognitive impairment or aphasia with inability to follow instructions
Severe pain in legs
Severe ankle contracture greater than 15° plantar flexion (when pushing ankle to dorsiflexion)
Pressure ulcer, recent surgical incision or active skin disease with open wounds present below knee

What this trial measures

  • Fugl-Meyer Lower Extremity (FMLE)At the beginning and end of 3-week training, and 1 month after the treatment ends]

    The Fugl-Meyer Lower Extremity (FMLE) assessment is a measure of lower extremity (LE) motor and sensory impairments. The FMLE scale ranges from 0 to 34, with higher scores indicating better motor function.