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NCT06406751

Microbiome Effects of Extended Use of MI Paste in Elderly Removable Denture Wearers

Enrolling by Invitation
NAAges 65+InterventionalTreatment
University of Iowa
~50 participants
Updated 2025-11-10 on ClinicalTrials.gov
What's tested:MI Paste

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assessment of changes in the oral microbiome composition over time
Measured over Multiple time points (baseline, two weeks, and four weeks)

Conditions

Dental Prosthesis

Explore related trials

Dental Prosthesis

Where it's being run

1 sites across 1 states
Iowa1

Study leadership

  • Robert Bowers, DDS · PRINCIPAL_INVESTIGATOR · University of Iowa

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Greater than or equal to 65 years of age,
Capacity to independently provide consent,
Having an adequately fitting removable complete maxillary (upper jaw) denture (no consideration relative to the presence or type of mandibular prosthesis (lower jaw partial or full denture).

Exclusion

ill-fitting complete denture(s),
presence of pathology indicated for immediate treatment (epulis fissuratum (excess folds of firm tissue form inside the mouth, as a result of rubbing on the edge of dentures that do not fit well), large denture sores),
currently or previously taking any form of antibiotics or antifungals (oral, intravenous, mouthwashes) over the previous two months that may impact microbial assessments.
a history of food-based allergies: casein, lactose, or food/cosmetic ingredient preservatives. These exclusions have been made out of an abundance of caution to avoid any potential adverse reaction to MI Paste which contains casein phosphopeptide--amorphous calcium phosphate (CPP-ACP), and several common preservative ingredients in oral care products that may induce sensitivities/allergic reaction in a small portion of the population.
milk allergy

What this trial measures

  • Assessment of changes in the oral microbiome composition over timeMultiple time points (baseline, two weeks, and four weeks)

    16S genomic profiling will be done in all recruited subjects via oral swab from under the denture and mouth tissues.